Watching A Snowflake Grow Seems Almost Magical–the Six-sided Shape, The Symmetry, The Way Every Arm

Are colour-changing octopuses really colourblind? 

Cephalopods, including octopuses and squid, have some of the most incredible colour-changing abilities in nature. 

They can almost instantly blend in with their surroundings to evade predators or lay in wait, and put on colourful displays to attract mates or dazzle potential prey.

This is impressive enough on its own, but becomes even more amazing when you discover these creatures are in fact colourblind – they only have one type of light receptor in their eyes, meaning they can only see in black and white.

So how do they know what colours to change to at all?

This has puzzled biologists for decades but a father/son team of scientists from the University of California, Berkeley, and Harvard University think the unusual shape of their pupils holds the key, and they can see colour after all.

Cephalopods have wide U-shaped or dumbbell-shaped pupils, which allow light into the lens from many directions.

When light enters the pupils in human eyes it gets focused on one spot, cutting down on blur from the light being split into its constituent colours.

The scientists believe cephalopod eyes work the opposite way – the wide pupils split the light up and then individual colours can be focused on the retina by changing the depth of the eyeball and moving the pupil around.  

The price for this is blurry vision, but it does mean they could make out colours in a unique way to any other animals.

Processing colour this way is more computationally intensive than other types of colour vision and likely requires a lot of brainpower, which might explain in part why cephalopods are the most intelligent invertebrates on Earth.

Read the paper

Images:  Roy Caldwell, Klaus Stiefel, Alexander Stubbs

The brilliant colors of a soap film reveal the fluid’s thickness, thanks to a process known as thin film interference. The twisting flow of the film depends on many influences: gravity pulls down on the liquid and tends to make it drain away; evaporation steals fluid from the film; local air currents can push or pull the film; and the variation in the concentration of molecules – specifically the surfactants that stabilize the film – will change the local surface tension, causing flow via the Marangoni effect. Together these and other effects create the dancing turbulence captured above. (Video credit: A. Filipowicz)

Got a chemistry-themed watch for Christmas - good for checking the time periodically 😃

Using the Power of Space to Fight Cancer

From cancer research to DNA sequencing, the International Space Space is proving to be an ideal platform for medical research. But new techniques in fighting cancer are not confined to research on the space station. Increasingly, artificial intelligence is helping to “read” large datasets. And for the past 15 years, these big data techniques pioneered by our Jet Propulsion Laboratory have been revolutionizing biomedical research.

Microgravity Research on Space Station

On Earth, scientists have devised several laboratory methods to mimic normal cellular behavior, but none of them work exactly the way the body does. Beginning more than 40 years ago aboard Skylab and continuing today aboard the space station, we and our partners have conducted research in the microgravity of space.  In this environment, in vitro cells arrange themselves into three-dimensional groupings, or aggregates. These aggregates more closely resemble what actually occurs in the human body. Cells in microgravity also tend to clump together more easily, and they experience reduced fluid shear stress – a type of turbulence that can affect their behavior. The development of 3D structure and enhanced cell differentiation seen in microgravity may help scientists study cell behavior and cancer development in models that behave more like tissues in the human body.

In addition, using the distinctive microgravity environment aboard the station, researchers are making further advancements in cancer therapy. The process of microencapsulation was investigated aboard the space station in an effort to improve the Earth-based technology. Microencapsulation is a technique that creates tiny, liquid-filled, biodegradable micro-balloons that can serve as delivery systems for various compounds, including specific combinations of concentrated anti-tumor drugs. For decades, scientists and clinicians have looked for the best ways to deliver these micro-balloons, or microcapsules, directly to specific treatment sites within a cancer patient, a process that has the potential to revolutionize cancer treatment.

A team of scientists at Johnson Space Center used the station as a tool to advance an Earth-based microencapsulation system, known as the Microencapsulation Electrostatic Processing System-II (MEPS-II), as a way to make more effective microcapsules. The team leveraged fluid behavior in microgravity to develop a new technique for making these microcapsules that would be more effective on Earth. In space, microgravity brought together two liquids incapable of mixing on Earth (80 percent water and 20 percent oil) in such a way that spontaneously caused liquid-filled microcapsules to form as spherical, tiny, liquid-filled bubbles surrounded by a thin, semipermeable, outer membrane. After studying these microcapsules on Earth, the team was able to develop a system to make more of the space-like microcapsules on Earth and are now performing activities leading to FDA approval for use in cancer treatment.  

In addition, the ISS National Laboratory managed by the Center for the Advancement of Science in Space (CASIS) has also sponsored cancer-related investigations.  An example of that is an investigation conducted by the commercial company Eli Lilly that seeks to crystallize a human membrane protein involved in several types of cancer together with a compound that could serve as a drug to treat those cancers. 

“So many things change in 3-D, it’s mind-blowing – when you look at the function of the cell, how they present their proteins, how they activate genes, how they interact with other cells,” said Jeanne Becker, Ph.D., a cell biologist at Nano3D Biosciences in Houston and principal investigator for a study called Cellular Biotechnology Operations Support Systems: Evaluation of Ovarian Tumor Cell Growth and Gene Expression, also known as the CBOSS-1-Ovarian study. “The variable that you are most looking at here is gravity, and you can’t really take away gravity on Earth. You have to go where gravity is reduced.“ 

Crunching Big Data Using Space Knowledge

Our Jet Propulsion Laboratory often deals with measurements from a variety of sensors – say, cameras and mass spectrometers that are on our spacecraft. Both can be used to study a star, planet or similar target object. But it takes special software to recognize that readings from very different instruments relate to one another.

There’s a similar problem in cancer research, where readings from different biomedical tests or instruments require correlation with one another. For that to happen, data have to be standardized, and algorithms must be “taught” to know what they’re looking for.

Because space exploration and cancer research share a similar challenge in that they both must analyze large datasets to find meaning, JPL and the National Cancer Institute renewed their research partnership to continue developing methods in data science that originated in space exploration and are now supporting new cancer discoveries.

JPL’s methods are leading to the development of a single, searchable network of cancer data that researcher can work into techniques for the early diagnosis of cancer or cancer risk. In the time they’ve worked together, the two organizations’ efforts have led to the discovery of six new Food and Drug Administration-approved cancer biomarkers. These agency-approved biomarkers have been used in more than 1 million patient diagnostic tests worldwide.

Memory Competition

Most of the brain contains cells that no longer divide and renew. However, the dentate gyrus, nestled within the memory-forming centre of the brain (the hippocampus) is one of the few sites where new cells continue to form throughout life. As a person ages, there is an ever-increasing struggle for these new dentate gyrus neurons (coloured pink) to integrate with existing older neurons (green) because the latter already has well-established connections. This may be why learning and memorisation becomes more difficult as a person gets older. Scientists have now found that by temporarily reducing the number of dendritic spines – branches of neurons that form connections with other neurons – in the mature cells, the new cells have a better chance of functionally integrating. Indeed, in live mice, briefly eliminating dendritic spines boosted the number of integrated new neurons, which rejuvenated the hippocampus and improved the animals’ memory precision.

Written by Ruth Williams

Image courtesy of Kathleen McAvoy

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA

Copyright held by original authors

Research published in Neuron, September 2016

You can also follow BPoD on Twitter and Facebook

Last Week In Science

1. Broad Institute wins CRISPR patent battle

basically UC Berkely has rights to use CRISPR in “all kinds of cells” and Broad has rights in “eukaryotic cells” (yay legal system). Anticipate more legal battles since there are more types of CRISPR techniques

2. Human genome editing gets the OK to prevent “serious heritable diseases and conditions only” 

Bioshock likely to happen in 50 years as “serious disease” dwindles in to “mediocre disease” and finally “what the hell let’s shoot fire from our hands”

3. With the EPA at risk of being destroyed, what was life like before the EPA?

4. Congress wants to shift Earth Science away from NASA (and focus on deep space)

4.1 Coders continue to save climate data

5. This years winners of underwater photos

6. Got trash on your power lines? That’s alright just attach a flamethrower to a drone, no worries 

7. Fungicides bring us closer to figuring out why all of the bees are dying

7.1 (but who cares right? we can just make quadcopters do all the work)

8. Australia is HOT AS BALLS

9. Aztecs probably died off from salmonella outbreak

10. Our genetic past and present sanitary world lead to increased autoimmunity and allergy

10.1 Getting the right microbiome early on is so important for health

11. New Zealand on a new continent might make maps include it more often

12. Now you realize how slow the speed of light is on a cosmic scale

13. Meta-Analysis shows Vitamin D supplementation provides “modest protective effect” from respiratory infections like the flu or cold

14. Watch Yosemite’s Horsetail and its annual “FireFall” (image via Robert Minor)

15. Trump’s press conference makes people wonder if he is mentally ill and if we should start testing old ass presidents for dementia

16. He continue’s to spew more anti-vaccine bullshit, showing his ignorance of science and RFK Jr.’s scam needs “just one study” to change his mind

16.1 more than 350 organizations write to Trump to assure his feeble mind that vaccines are safe

17. Simple fractal patterns are key to Rorschach test

18. Imagine shining a light somewhere on your body and microscopic bots deliver drugs there

19. How flat can a planet be?

20. Triangulene created for the first time

Who needs carefully planned chemical reactions when you can just blast hydrogens off with electricity?

21. All of the nerdy. Valentine’s. you. will. ever. need. 

22. Help find Planet 9 in your spare time

22.1 Don’t have time? then do science while your computer is idle!

Thumpety thump thump thumpety thump thump look at Kinesin go

Myosin, kinesin, and dynein are important proteins governing internal transport. Myosin attached to organelles associates with actin microfilaments to enable the continuous flow of cytoplasm called cytoplasmic streaming.

Kinesins and dynein enable the movement of organelles along microtubules. They attach and move along microtubules. Most kinesins transport organelles from the center towards the periphery of the cell, anterograde transport. Dynein, and a few types of kinesins transport towards the cell center, retrograde transport.

(via thelifeofapremed)

I gotta split! Image of the Week - June 22, 2015

CIL:41466 - http://www.cellimagelibrary.org/images/41466

Description: Confocal image of a mitotic spindle in a dividing cell. The spindle is shown in yellow and the surrounding actin cytoskeleton is in blue. Sixth Prize, 2007 Olympus BioScapes Digital Imaging Competition.

Authors: Patricia Wadsworth and the 2007 Olympus Bioscapes Digital Imaging Competition®.

Licensing: Attribution Non-Commercial No Derivatives: This image is licensed under a Creative Commons Attribution, Non-Commercial, No Derivatives License

Marrow Christmas and a Happy New Smear!

A very seasonal smear made from red marrow extracted from the iliac crest of a donor’s pelvis prior to transplantation.

Happy Holidays everyone

i♡histo

The image amazingly captures a single moment in time during the development of thousands of red and white blood cells.

Many of the small cells that are visible, like the ones forming the snowman’s carrot nose, do not have a nucleus. These are brand new erythrocytes (red blood cells) that are ready to exit the bone and enter the blood stream.

The other, slightly larger cells that have nuclei, like the snowman’s eyes and his top button, are either precursors to these erythrocytes (they will mature and lose their nucleus) or are precursors to the other blood cells in our body, the leukocytes (white blood cells): lymphocytes, monocytes, neutrophils, eosinophils and basophils.

In addition, the bone marrow is home to the cells that form platelets. These are huge multinucleated cells aptly named megakaryocytes - perhaps the cell at the bottom right.

It is possible to identify each mature cell and its precursor based upon its morphology and staining at higher magnification. High or low levels of these cells can indicate disease or cancers of the blood.