Untitled // Jake Chamseddine
Sunday’s are for relaxing with a good book.
Chances are you or somebody you know has recently become the owner of an Instant Pot, the multifunction electric pressure cooker that can produce fork-tender pot roasts in less than an hour, as well as brown meat, cook beans without soaking, and even do the job of a rice cooker or crockpot. The Instant Pot isn’t advertised on TV or in the newspapers, and yet it’s become a viral marketing success story, with owners often describing themselves as “addicts” or “cult members.” That’s the kind of word-of-mouth publicity Instant Pot founders dreamed of when they first began designing the countertop appliances.
The Instant Pot electric pressure cooker has been around since 2010, but really became the buzz during the last six months of 2016. While the company’s electric pressure cookers are sold at Wal-Mart, Target and Kohl’s, the bulk of its sales come from Amazon, driven by social media. Deep discounts on Amazon Prime Day and again on Black Friday, along with the viral online sharing of these sales, turned Instant Pot into a household name. With 215,000 units sold on Prime Day alone, the Instant Pot Duo is Amazon’s top-selling item in the U.S. market. Not bad for a company that does no TV or print advertising and only recently began the process of hiring a marketing agency.
Photo: Grace Hwang Lynch
According to legend, Pythagoras invented a cup to prevent his students from drinking too greedily. If they overfilled the cup, it would immediately drain out all the fluid. The trick works thanks to a U-shaped tube in the center of the cup. As long as the liquid level is below the highest point in the U-tube, only the entrance side of the tube will be filled. As soon as the liquid level in the cup is higher, the weight of all that fluid forces liquid up and around the bend. This kicks off a siphoning effect that pulls all the fluid out. Coincidentally, this is the same way that toilet flushing works! Pulling the handle releases extra water into the bowl that raises the fluid level higher than the highest point in a U-bend. That establishes a siphon, which (provided nothing has clogged the pipe), empties the toilet bowl. (Video credit: Periodic Videos)
Man dies. Come from darkness, into darkness he returns, and is reabsorbed, without a trace left, into the illimitable void of time.
Leonid Andreyev. (via drunk-on-books)
Researchers identify method of creating long-lasting memories
Imagine if playing a new video game or riding a rollercoaster could help you prepare for an exam or remember other critical information.
A new study in mice shows this link may be possible.
Attention-grabbing experiences trigger the release of memory-enhancing chemicals. Those chemicals can etch memories into the brain that occur just before or soon after the experience, regardless of whether they were related to the event, according to researchers at UT Southwestern Medical Center’s Peter O’Donnell Jr. Brain Institute.
The findings, published in Nature, hold intriguing implications for methods of learning in classrooms as well as an array of potential uses in the workplace and personal life, researchers said.
The trick to creating long-lasting memories is to find something interesting enough to activate the release of dopamine from the brain’s locus coeruleus (LC) region.
“Activation of the locus coeruleus increases our memory of events that happen at the time of activation and may also increase the recall of those memories at a later time,” said Dr. Robert Greene, the study’s co-senior author and a Professor of Psychiatry and Neurosciences with the O’Donnell Brain Institute.
The study explains at the molecular level why people tend to remember certain events in their lives with particular clarity as well as unrelated details surrounding those events: for instance, what they were doing in the hours before the Sept. 11, 2001, terrorist attacks; or where they were when John F. Kennedy was assassinated.
“The degree to which these memories are enhanced probably has to do with the degree of activation of the LC,” said Dr. Greene, holder of the Sherry Gold Knopf Crasilneck Distinguished Chair in Psychiatry, in Honor of Mollie and Murray Gold, and the Sherry Knopf Crasilneck Distinguished Chair in Psychiatry, in Honor of Albert Knopf. “When the New York World Trade Center came down on 9/11, that was high activation.”
But life-changing events aren’t the only way to trigger the release of dopamine in this part of the brain. It could be as simple as a student playing a new video game during a quick break while studying for a crucial exam, or a company executive playing tennis right after trying to memorize a big speech.
“In general, anything that will grab your attention in a persistent kind of way can lead to activation,” Dr. Greene said.
Scientists have known dopamine plays a large role in memory enhancement, though where the chemical originates and how it’s triggered have been points of study over the years.
Dr. Greene led a study published in 2012 that identified the locus coeruleus as a third key source for dopamine in the brain, besides the ventral tegmental area and the substantia nigra. That research demonstrated the drug amphetamine could pharmacologically trigger the brain’s release of dopamine from the LC.
The latest study builds upon those findings, establishing that dopamine in this area of the brain can be naturally activated through behavioral actions and that these actions enhance memory retention.
The new study suggests that drugs targeting neurons in the locus coeruleus may affect learning and memory as well. The LC is located in the brain stem and has a range of functions that affect a person’s emotions, anxiety levels, sleep patterns, memory and other aspects of behavior.
The study tested 120 mice to establish a link between locus coeruleus neurons and neuronal circuits of the hippocampus – the region of the brain responsible for recording memories – that receive dopamine from the LC.
One part of the research involved putting the mice in an arena to search for food hidden in sand that changed location each day. The study found that mice that were given a “novel experience” – exploring an unfamiliar floor surface 30 minutes after being trained to remember the food location – did better in remembering where to find the food the next day.
Researchers correlated this memory enhancement to a molecular process in the brain by injecting the mice with a genetically encoded light-sensitive activator called channelrhodopsin. This sensor allowed them to selectively activate dopamine-carrying neurons of the locus coeruleus that go to the hippocampus and to see first-hand which neurons were responsible for the memory enhancement.
They found that selectively activating the channelrhodopsin-labeled neurons with blue light (a technique called optogenetics) could substitute for the novelty experience as a memory enhancer in mice. They also found that this activation could cause a direct, long-lasting synaptic strengthening – an enhancement of memory-relevant communication occurring at the junctions between neurons in the hippocampus. This process can mediate improvement of learning and memory.
Some next steps include investigating how big an impact this finding can have on human learning, whether it can eventually lead to an understanding of how patients can develop failing memories, and how to better target effective therapies for these patients, said Dr. Greene.
Perfect
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“One of the things I always admired about Clark Gable was between scenes, he didn’t go lock himself up in his trailer. He would hang out with the guys, the electricians, they all loved him. He was not full of himself. It was nothing to come to set and find him straddling a bench, playing gim rummy with the crew.” -Ann Rutherford
Sixty Symbols has a great new video explaining the laboratory set-up for demoing a Kelvin-Helmholtz instability. You can see a close-up from the demo above. Here the pink liquid is fresh water and the blue is slightly denser salt water. When the tank holding them is tipped, the lighter fresh water flows upward while the salt water flows down. This creates a big velocity gradient and lots of shear at the interface between them. The situation is unstable, meaning that any slight waviness that forms between the two layers will grow (exponentially, in this case). Note that for several long seconds, it seems like nothing is happening. That’s when any perturbations in the system are too small for us to see. But because the instability causes those perturbations to grow at an exponential rate, we see the interface go from a slight waviness to a complete mess in only a couple of seconds. The Kelvin-Helmholtz instability is incredibly common in nature, appearing in clouds, ocean waves, other planets’ atmospheres, and even in galaxy clusters! (Image and video credit: Sixty Symbols)
The James Webb Space Telescope’s gold-plated, beryllium mirrors are beautiful feats of engineering. From the 18 hexagonal primary mirror segments, to the perfectly circular secondary mirror, and even the slightly trapezoidal tertiary mirror and the intricate fine-steering mirror, each reflector went through a rigorous refinement process before it was ready to mount on the telescope. This flawless formation process was critical for Webb, which will use the mirrors to peer far back in time to capture the light from the first stars and galaxies.
The James Webb Space Telescope, or Webb, is our upcoming infrared space observatory, which will launch in 2019. It will spy the first luminous objects that formed in the universe and shed light on how galaxies evolve, how stars and planetary systems are born, and how life could form on other planets.
A polish and shine that would make your car jealous
All of the Webb telescope’s mirrors were polished to accuracies of approximately one millionth of an inch. The beryllium mirrors were polished at room temperature with slight imperfections, so as they change shape ever so slightly while cooling to their operating temperatures in space, they achieve their perfect shape for operations.
The Midas touch
Engineers used a process called vacuum vapor deposition to coat Webb’s mirrors with an ultra-thin layer of gold. Each mirror only required about 3 grams (about 0.11 ounces) of gold. It only took about a golf ball-sized amount of gold to paint the entire main mirror!
Before the deposition process began, engineers had to be absolutely sure the mirror surfaces were free from contaminants.
The engineers thoroughly wiped down each mirror, then checked it in low light conditions to ensure there was no residue on the surface.
Inside the vacuum deposition chamber, the tiny amount of gold is turned into a vapor and deposited to cover the entire surface of each mirror.
Primary, secondary, and tertiary mirrors, oh my!
Each of Webb’s primary mirror segments is hexagonally shaped. The entire 6.5-meter (21.3-foot) primary mirror is slightly curved (concave), so each approximately 1.3-meter (4.3-foot) piece has a slight curve to it.
Those curves repeat themselves among the segments, so there are only three different shapes — 6 of each type. In the image below, those different shapes are labeled as A, B, and C.
Webb’s perfectly circular secondary mirror captures light from the 18 primary mirror segments and relays those images to the telescope’s tertiary mirror.
The secondary mirror is convex, so the reflective surface bulges toward a light source. It looks much like a curved mirror that you see on the wall near the exit of a parking garage that lets motorists see around a corner.
Webb’s trapezoidal tertiary mirror captures light from the secondary mirror and relays it to the fine-steering mirror and science instruments. The tertiary mirror sits at the center of the telescope’s primary mirror. The tertiary mirror is the only fixed mirror in the system — all of the other mirrors align to it.
All of the mirrors working together will provide Webb with the most advanced infrared vision of any space observatory we’ve ever launched!
Who is the fairest of them all?
The beauty of Webb’s primary mirror was apparent as it rotated past a cleanroom observation window at our Goddard Space Flight Center in Greenbelt, Maryland. If you look closely in the reflection, you will see none other than James Webb Space Telescope senior project scientist and Nobel Laureate John Mather!
Learn more about the James Webb Space Telescope HERE, or follow the mission on Facebook, Twitter and Instagram.
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