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Info Post #1: What is DNA?

This is the first of thirteen more in-depth write-ups I have planned out for this year. The list (which is not set in stone!) can be found here.

I decided to do these as a way to get more information out to the readers here without having to delve into one specific ask or series of questions. I can imagine that these might create more questions as I go, but I’m also hoping that they will provide a resource that readers can refer back to. The general idea is to allow the series to build up in complexity, and give everyone a better understanding of these topics!

What is DNA?

This first topic is going to be relatively short, because in a couple of weeks I am going to do “what is a gene”, which will get much longer and more complicated, but I wanted some set up about the physical structure of DNA.

You might have heard DNA described in a lot of different ways. Deoxyribonucleic acid. The building blocks of life. The blueprint of You. None of these are particularity inaccurate, but I don’t think that any of them are super great descriptors of what exactly DNA is, or how exactly it goes from existing in cells to encoding entire organisms (although I am going to talk about the actual encoding part in the future).

For now, we are going to start small. Let’s only look at the actual physical structure. Here we have a DNA molecule:

image from wikimedia commons here

So beautiful! (I might be biased, but DNA is my favourite molecule- it’s elegant in both design and function.)

This can be broken down into two main parts:

The phosphate-sugar backbone (all those P’s and O’s and light blue on the outside)

The nucleobases (adenine [A], thymine [T], cytosine [C], and guanine [G]- the purple, pink, yellow and green)

I will point out the hydrogen bonds in the middle as well. Note that cytosine and guanine have three bonds between them, and adenine and thymine only have two. These molecules always bond in this pattern (A bonds to T, and C to G). If you’ve heard DNA being described as “complementary”, this is why! If you find a C on one strand, you know that you will find a G on the other (this became very important for sequencing, but we will talk about that later).

The hydrogen bonds in the middle are quite important as well. If these molecules were bonded to each other directly, it would be basically impossible to open the strand to “read” the DNA. Instead, this can be done by breaking those hydrogen bonds, and then allowing them to reform. This does mean that a mutation is much more likely in a high A-T region rather than a high C-G on, simply because A-T only has two bonds, and C-G has three. As well, quite often before a gene is encoded, there’s a long stretch of TATA- repeated (these are cleverly called TATA-boxes), so that the strand can more easily be opened and the encoded gene read. More on that when I talk about what a gene is!

And that is honestly pretty much it for DNA (I say that in jest- there is a lot more, and this is the result of a few billion years of evolution!). It’s not a terribly complicated design, which is probably why it is so immensely biologically successful.

So, there we have it: a very, very quick rundown that is mostly to get some important features pointed out before I talk about what a gene is, and how DNA encodes them on January 31st. This is hardly comprehensive, but I will get more in-depth into the structure and features then, and I didn’t want to make that info post horrendously long. Thanks for reading!

The smell of men’s cologne has been found to reduce blood flow to the vagina. Source

Scientists just figured out why poison ivy makes us itch so much

Leaves of three, let them be.

An international team of researchers has finally decoded the science behind a plant responsible for no small degree of human misery: poison ivy.

For the first time, we now know why poison ivy leaves – the bane of campers, hikers, and overly curious kids alike – make us itch, and the answer lies in a key molecule called CD1a, which scientists have long known about but didn’t fully understand until now.

“For over 35 years we have known CD1a is abundant in the skin,” says researcher Jerome Le Nours from Monash University in Australia. “Its role in inflammatory skin disorders has been difficult to investigate and until now has been really unclear.”

One of the reasons for that lack of clarity has been that many experiments on skin disorders involve animal testing – specifically lab mice. And mice don’t produce CD1a, effectively creating a kind of ‘blind spot’ in the studies up to this point.

To get around this and examine whether CD1a might play a part in how human skin reacts when we brush up against poison ivy (Toxicodendron radicans) and similar rash-inducing plants, the researchers genetically engineered mice that did produce the molecule.

In doing so, the team found that CD1a – a protein that plays an important role in our immune systems – triggers a skin-based allergic reaction when we come into contact with urushiol, the allergen that functions as the active ingredient in plants like poison ivy, poison oak, and poison sumac.

When urushiol interacts with skin cells called Langerhans cells, the CD1a proteins (which are expressed by Langerhans cells) activate the immune system’s T cells. In turn, the T cells produce two proteins – interleukin 17 and interleukin 22 – which cause inflammation and itchiness.

Continue Reading.

If Earth had Saturn’s Rings

From an excellent post by Jason Davis

From Washington, D.C., the rings would only fill a portion of the sky, but appear striking nonetheless. Here, we see them at sunrise.

From Guatemala, only 14 degrees above the equator, the rings would begin to stretch across the horizon. Their reflected light would make the moon much brighter.

From Earth’s equator, Saturn’s rings would be viewed edge-on, appearing as a thin, bright line bisecting the sky.

At the March and September equinoxes, the Sun would be positioned directly over the rings, casting a dramatic shadow at the equator.

At midnight at the Tropic of Capricorn, which sits at 23 degrees south latitude, the Earth casts a shadow over the middle of the rings, while the outer portions remain lit.

via x

Oh hey, not a big deal, but the hubble took a picture of a star that’s nearing supernova status 

A human brain has around 86 billion neurons, and the communication between these neurons are constant. The sheer scale of these interactions mean a computer (an EEG) can register this electrical activity, with different frequencies indicating different mental states.

Sources

NASA’S TESS ROUNDS UP ITS FIRST PLANETS, SNARES FAR-FLUNG SUPERNOVAE

NASA’s Transiting Exoplanet Survey Satellite (TESS) has found three confirmed exoplanets, or worlds beyond our solar system, in its first three months of observations.

The mission’s sensitive cameras also captured 100 short-lived changes – most of them likely stellar outbursts – in the same region of the sky. They include six supernova explosions whose brightening light was recorded by TESS even before the outbursts were discovered by ground-based telescopes.

The new discoveries show that TESS is delivering on its goal of discovering planets around nearby bright stars. Using ground-based telescopes, astronomers are now conducting follow-up observations on more than 280 TESS exoplanet candidates.

The first confirmed discovery is a world called Pi Mensae c about twice Earth’s size. Every six days, the new planet orbits the star Pi Mensae, located about 60 light-years away and visible to the unaided eye in the southern constellation Mensa. The bright star Pi Mensae is similar to the Sun in mass and size.

“This star was already known to host a planet, called Pi Mensae b, which is about 10 times the mass of Jupiter and follows a long and very eccentric orbit,” said Chelsea Huang, a Juan Carlos Torres Fellow at the Massachusetts Institute of Technology’s (MIT) Kavli Institute for Astrophysics and Space Research (MKI) in Cambridge. “In contrast, the new planet, called Pi Mensae c, has a circular orbit close to the star, and these orbital differences will prove key to understanding how this unusual system formed.”

Next is LHS 3884b, a rocky planet about 1.3 times Earth’s size located about 49 light-years away in the constellation Indus, making it among the closest transiting exoplanets known. The star is a cool M-type dwarf star about one-fifth the size of our Sun. Completing an orbit every 11 hours, the planet lies so close to its star that some of its rocky surface on the daytime side may form pools of molten lava.

The third – and possibly fourth – planets orbit HD 21749, a K-type star about 80 percent the Sun’s mass and located 53 light-years away in the southern constellation Reticulum.

The confirmed planet, HD 21749b, is about three times Earth’s size and 23 times its mass, orbits every 36 days, and has a surface temperature around 300 degrees Fahrenheit (150 degrees Celsius). “This planet has a greater density than Neptune, but it isn’t rocky. It could be a water planet or have some other type of substantial atmosphere,” explained Diana Dragomir, a Hubble Fellow at MKI and lead author of a paper describing the find. It is the longest-period transiting planet within 100 light-years of the solar system, and it has the coolest surface temperature of a transiting exoplanet around a star brighter than 10th magnitude, or about 25 times fainter than the limit of unaided human vision.

What’s even more exciting are hints the system holds a second candidate planet about the size of Earth that orbits the star every eight days. If confirmed, it could be the smallest TESS planet to date.

TESS’s four cameras, designed and built by MKI and MIT’s Lincoln Laboratory in Lexington, Massachusetts, spend nearly a month monitoring each observing sector, a single swath of the sky measuring 24 by 96 degrees. The primary aim is to look for exoplanet transits, which occur when a planet passes in front of its host star as viewed from TESS’s perspective. This causes a regular dip in the measured brightness of the star that signals a planet’s presence.

In its primary two-year mission, TESS will observe nearly the whole sky, providing a rich catalog of worlds around nearby stars. Their proximity to Earth will enable detailed characterization of the planets through follow-up observations from space- and ground-based telescopes.

But in its month-long stare into each sector, TESS records many additional phenomena, including comets, asteroids, flare stars, eclipsing binaries, white dwarf stars and supernovae, resulting in an astronomical treasure trove.

In the first TESS sector alone, observed between July 25 and Aug. 22, 2018, the mission caught dozens of short-lived, or transient, events, including images of six supernovae in distant galaxies that were later seen by ground-based telescopes.

“Some of the most interesting science occurs in the early days of a supernova, which has been very difficult to observe before TESS,” said Michael Fausnaugh, a TESS researcher at MKI. “NASA’s Kepler space telescope caught five of these events as they brightened during its first four years of operations. TESS found as many in its first month.”

These early observations hold the key to understanding a class of supernovae that serve as an important yardstick for cosmological studies. Type Ia supernovae form through two channels. One involves the merger of two orbiting white dwarfs, compact remnants of stars like the Sun. The other occurs in systems where a white dwarf draws gas from a normal star, gradually gaining mass until it becomes unstable and explodes. Astronomers don’t know which scenario is more common, but TESS could detect modifications to the early light of the explosion caused by the presence of a stellar companion.

All science data from the first two TESS observation sectors were recently released to the scientific community through the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute in Baltimore.

More than a million TESS images were downloaded from MAST in the first few days,” said Thomas Barclay, a TESS researcher at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, and the University of Maryland, Baltimore County. “The astronomical community’s reaction to the early data release showed us that the world is ready to jump in and add to the mission’s scientific bounty.

George Ricker, the mission’s principal investigator at MKI, said that TESS’s cameras and spacecraft were performing superbly. “We’re only halfway through TESS’s first year of operations, and the data floodgates are just beginning to open,” he said. “When the full set of observations of more than 300 million stars and galaxies collected in the two-year prime mission are scrutinized by astronomers worldwide, TESS may well have discovered as many as 10,000 planets, in addition to hundreds of supernovae and other explosive stellar and extragalactic transients.”

About 400 million years ago, before trees were common, the Earth was covered with giant mushrooms. Source

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