I like the idea of putting my blorbos on the Infinity Train. Force them to go through a harrowing experience specially fashioned to make them work through their issues (and leave them with a new set of issues afterwards)
So here's Bonesaw! She needs to stop thinking of other human beings and little more than art supplies. And being stuck on the Train for an indeterminate length of time will forcibly separate her from Jack, so she can begin to build an identity of her own for the first time in her life.