I've been thinking about two lines-
One from the Demigod Files, where Annabeth says that Percy is smart but acts pretty dumb sometimes, and the second from the Mark of Athena where Piper notes that Annabeth wasn't around to 'rein Percy in' when he was taunting Bacchus.
Does this mean that Annabeth often has to stop Percy from pissing off the gods and that it exhausts her? There's reasonable evidence for this.
He pissed off Ares in TLT, Hera in BOTL and Bacchus in MOA. We know that Percy has a history of pissing off gods, which is why it's such a trademark characteristic of his in the fandom. Piper notes that Annabeth isn't around to rein him in, which means that Annabeth would have stopped Percy from pissing off Bacchus if she had been there. Given how Percy acted towards Bacchus, he wouldn't have been to easy to stop. And keep in mind that that's a god. It doesn't matter if it's Percy Jackson talking to him-there's a very real chance of them killing him, because if Zeus can give Percy 3 quests after Percy saved the world twice, then any god can kill Percy and not suffer divine consequence.
If that's the case, then I feel sorry for Annabeth because she has to calm him down and stop him from pissing off the gods. It must be exhausting for her.