I really don't understand why it's said that she literally doesn't know how to communicate with people, because until now I've only seen the opposite among her friends. In fact, Gwen is one of those people who, the more trust they have towards the other person, the more open they are, it's not something weird and it's something very different from "Not knowing how to interact with anyone"
Besides, "Losing the sanity" is not the appropriate term to refer to her situation either in the prologue or when she was kicked out of the Spider-Society, another VERY different thing is that she has been desperate, that she does not know what to do, nor anyone to go to, because if she had really "almost lost her sanity" she would have gone totally crazy until she sank into dementia, something she was never even close to being in that situation, in fact, the only two characters who were really on the verge of losing his sanity were Miguel and, of course, Miles, who with the short "The Spider Within" we saw how really broken he was inside, and even worse after ATSV.
gwen is so funny as a character. we saw her as such a Cool Teenage Girl in the first movie. she figured out so young how to be spiderwoman, beat bullies at school to protect her friend, is a punk, a drummer in a band, does ballet and adds the grace of her movements to her swinging and fight style, makes her own clothes and changes her hair every month, etc etc.
all that only for us to find out the most important thing about her character is she's a LOSER despite all that. she can't make friends except for peter, can't communicate with people properly, makes a fool of herself in front of her crush's parents, makes terrible decisions under pressure and tries to avoid conflict until she's on the verge of losing sanity.
and ykw? that's exactly why i adore her character so much. fake girlfailure lovers when real girlfailures (gwen stacy) come at them: oh no why would this traumatized homeless & alienated teenager do this....kill it with fire