Why Webb Needs To Chill

The U.S. Women’s Team win gold at the 2014 Nanning World Championships

New discovery could be a major advance for understanding neurological diseases

The discovery of a new mechanism that controls the way nerve cells in the brain communicate with each other to regulate our learning and long-term memory could have major benefits to understanding how the brain works and what goes wrong in neurodegenerative disorders such as epilepsy and dementia. The breakthrough, published in Nature Neuroscience, was made by scientists at the University of Bristol and the University of Central Lancashire.   The findings will have far-reaching implications in many aspects of neuroscience and understanding how the brain works.

The human brain contains around 100-billion nerve cells, each of which makes about 10,000 connections to other cells, called synapses. Synapses are constantly transmitting information to, and receiving information from other nerve cells. A process, called long-term potentiation (LTP), increases the strength of information flow across synapses. Lots of synapses communicating between different nerve cells form networks and LTP intensifies the connectivity of the cells in the network to make information transfer more efficient. This LTP mechanism is how the brain operates at the cellular level to allow us to learn and remember. However, when these processes go wrong they can lead to neurological and neurodegenerative disorders.

Precisely how LTP is initiated is a major question in neuroscience. Traditional LTP is regulated by the activation of special proteins at synapses called NMDA receptors. This study, by Professor Jeremy Henley and co-workers reports a new type of LTP that is controlled by kainate receptors.

This is an important advance as it highlights the flexibility in the way synapses are controlled and nerve cells communicate. This, in turn, raises the possibility of targeting this new pathway to develop therapeutic strategies for diseases like dementia, in which there is too little synaptic transmission and LTP, and epilepsy where there is too much inappropriate synaptic transmission and LTP.

Jeremy Henley, Professor of Molecular Neuroscience in the University’s School of Biochemistry in the Faculty of Biomedical Sciences, said: “These discoveries represent a significant advance and will have far-reaching implications for the understanding of memory, cognition, developmental plasticity and neuronal network formation and stabilisation. In summary, we believe that this is a groundbreaking study that opens new lines of inquiry which will increase understanding of the molecular details of synaptic function in health and disease.”

Dr Milos Petrovic, co-author of the study and Reader in Neuroscience at the University of Central Lancashire added: “Untangling the interactions between the signal receptors in the brain not only tells us more about the inner workings of a healthy brain, but also provides a practical insight into what happens when we form new memories. If we can preserve these signals it may help protect against brain diseases.

“This is certainly an extremely exciting discovery and something that could potentially impact the global population. We have discovered potential new drug targets that could help to cure the devastating consequences of dementias, such as Alzheimer’s disease. Collaborating with researchers across the world in order to identify new ways to fight disease like this is what world-class scientific research is all about, and we look forward to continuing our work in this area.”

Studio Ghibli + Food

Spacewalk Recap Told in GIFs

Friday, Oct. 20, NASA astronauts Randy Bresnik and Joe Acaba ventured outside the International Space Station for a 6 hour and 49 minute spacewalk. Just like you make improvements to your home on Earth, astronauts living in space periodically go outside the space station to make updates on their orbiting home.

During this spacewalk, they did a lot! Here’s a recap of their day told in GIFs…

All spacewalks begin inside the space station. Astronauts Paolo Nespoli and Mark Vande Hei helped each spacewalker put on their suit, known as an Extravehicular Mobility Unit (EMU).

They then enter an airlock and regulate the pressure so that they can enter the vacuum of space safely. If they did not regulate the pressure safely, the astronauts could experience something referred to as “the bends” – similar to scuba divers.

Once the two astronauts exited the airlock and were outside the space station, they went to their respective work stations.

Bresnik replaced a failed fuse on the end of the Dextre robotic arm extension, which helps capture visiting vehicles.

During that time, Acaba set up a portable foot restraint to help him get in the right position to install a new camera.

While he was getting set up, he realized that there was unexpected wearing on one of his safety tethers. Astronauts have multiple safety mechanisms for spacewalking, including a “jet pack” on their spacesuit. That way, in the unlikely instance they become untethered from the station, the are able to propel back to safety.

Bresnik was a great teammate and brought Acaba a spare safety tether to use.

Once Acaba secured himself in the foot restraint that was attached to the end of the station’s robotic arm, he was maneuvered into place to install a new HD camera. Who was moving the arm? Astronauts inside the station were carefully moving it into place!

And, ta da! Below you can see one of the first views from the new enhanced HD camera…(sorry, not a GIF).

After Acaba installed the new HD camera, he repaired the camera system on the end of the robotic arm’s hand. This ensures that the hand can see the vehicles that it’s capturing.

Bresnik, completed all of his planned tasks and moved on to a few “get ahead” tasks. He first started removing extra thermal insulation straps around some spare pumps. This will allow easier access to these spare parts if and when they’re needed in the future.

He then worked to install a new handle on the outside of space station. That’s a space drill in the above GIF. 

After Acaba finished working on the robotic arm’s camera, he began greasing bearings on the new latching end effector (the arm’s “hand”), which was just installed on Oct. 5.

The duo completed all planned spacewalk tasks, cleaned up their work stations and headed back to the station’s airlock. 

Once safely inside the airlock and pressure was restored to the proper levels, the duo was greeted by the crew onboard. 

They took images of their spacesuits to document any possible tears, rips or stains, and took them off. 

Coverage ended at 2:36 p.m. EDT after 6 hours and 49 minutes. We hope the pair was able to grab some dinner and take a break!

You can watch the entire spacewalk HERE, or follow @Space_Station on Twitter and Instagram for regular updates on the orbiting laboratory. 

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

Major Research Instrumentation Program

Credit: Photo by Lance Long; courtesy Electronic Visualization Laboratory, University of Illinois at Chicago

The Major Research Instrumentation program has helped to fund pieces of research equipment ranging from scanning probe microscopes, which have helped to visualize and characterize nano-scale biological tools, to nuclear magnetic resonance (NMR) spectrometers, which allow chemists to identify the individual molecules they make. Not only does this instrumentation help scientists advance their own research, it’s also used to train the next generation of scientists. For example, an X-ray diffractometer at Utah State University allowed Joan Hevel and Sean Johnson to teach four high school students in their lab about protein crystallization. Learn more.

Tuz Gölü - Cereal  / WORDS & PHOTOS: Peter Edel

FOR THE AMERICAN COLOUR FIELD PAINTER BARNETT NEWMAN, THE EMPTY, BOUNDLESS LANDSCAPE ENHANCED AN INDIVIDUAL’S SENSE OF PRESENCE WITHIN THEM. THE TUZ GÖLÜ, THE SALT LAKE LOCATED IN THE CORE OF TURKEY’S ANATOLIAN PENINSULA, IS ONE OF THE PLACES IN THE WORLD WHERE THIS UNDERSTANDING IS EXPERIENCED MOST PROFOUNDLY.

Mulan (1998)

Unusual Insects Taking Off

What do you do when you’re an insect researcher with a high-speed camera? Why, film all sorts of unusual insects from your backyard as they take off and fly! (Image and video credit: Ant Lab/A. Smith; via Colossal) Read the full article

Method of teaching.. method of communication

Study Finds Students Of All Races Prefer Teachers Of Color

Regardless of their own race, students had more favorable perceptions of teachers of color, according to a new study from New York University.