New Discovery Could Be A Major Advance For Understanding Neurological Diseases

New discovery could be a major advance for understanding neurological diseases

The discovery of a new mechanism that controls the way nerve cells in the brain communicate with each other to regulate our learning and long-term memory could have major benefits to understanding how the brain works and what goes wrong in neurodegenerative disorders such as epilepsy and dementia. The breakthrough, published in Nature Neuroscience, was made by scientists at the University of Bristol and the University of Central Lancashire. The findings will have far-reaching implications in many aspects of neuroscience and understanding how the brain works.

The human brain contains around 100-billion nerve cells, each of which makes about 10,000 connections to other cells, called synapses. Synapses are constantly transmitting information to, and receiving information from other nerve cells. A process, called long-term potentiation (LTP), increases the strength of information flow across synapses. Lots of synapses communicating between different nerve cells form networks and LTP intensifies the connectivity of the cells in the network to make information transfer more efficient. This LTP mechanism is how the brain operates at the cellular level to allow us to learn and remember. However, when these processes go wrong they can lead to neurological and neurodegenerative disorders.

Precisely how LTP is initiated is a major question in neuroscience. Traditional LTP is regulated by the activation of special proteins at synapses called NMDA receptors. This study, by Professor Jeremy Henley and co-workers reports a new type of LTP that is controlled by kainate receptors.

This is an important advance as it highlights the flexibility in the way synapses are controlled and nerve cells communicate. This, in turn, raises the possibility of targeting this new pathway to develop therapeutic strategies for diseases like dementia, in which there is too little synaptic transmission and LTP, and epilepsy where there is too much inappropriate synaptic transmission and LTP.

Jeremy Henley, Professor of Molecular Neuroscience in the University’s School of Biochemistry in the Faculty of Biomedical Sciences, said: “These discoveries represent a significant advance and will have far-reaching implications for the understanding of memory, cognition, developmental plasticity and neuronal network formation and stabilisation. In summary, we believe that this is a groundbreaking study that opens new lines of inquiry which will increase understanding of the molecular details of synaptic function in health and disease.”

Dr Milos Petrovic, co-author of the study and Reader in Neuroscience at the University of Central Lancashire added: “Untangling the interactions between the signal receptors in the brain not only tells us more about the inner workings of a healthy brain, but also provides a practical insight into what happens when we form new memories. If we can preserve these signals it may help protect against brain diseases.

“This is certainly an extremely exciting discovery and something that could potentially impact the global population. We have discovered potential new drug targets that could help to cure the devastating consequences of dementias, such as Alzheimer’s disease. Collaborating with researchers across the world in order to identify new ways to fight disease like this is what world-class scientific research is all about, and we look forward to continuing our work in this area.”

Why Webb Needs to Chill

Our massive James Webb Space Telescope is currently being tested to make sure it can work perfectly at incredibly cold temperatures when it’s in deep space.

How cold is it getting and why? Here’s the whole scoop…

Webb is a giant infrared space telescope that we are currently building. It was designed to see things that other telescopes, even the amazing Hubble Space Telescope, can’t see.

Webb’s giant 6.5-meter diameter primary mirror is part of what gives it superior vision, and it’s coated in gold to optimize it for seeing infrared light.

Why do we want to see infrared light?

Lots of stuff in space emits infrared light, so being able to observe it gives us another tool for understanding the universe. For example, sometimes dust obscures the light from objects we want to study – but if we can see the heat they are emitting, we can still “see” the objects to study them.

It’s like if you were to stick your arm inside a garbage bag. You might not be able to see your arm with your eyes – but if you had an infrared camera, it could see the heat of your arm right through the cooler plastic bag.

Credit: NASA/IPAC

With a powerful infrared space telescope, we can see stars and planets forming inside clouds of dust and gas.

We can also see the very first stars and galaxies that formed in the early universe. These objects are so far away that…well, we haven’t actually been able to see them yet. Also, their light has been shifted from visible light to infrared because the universe is expanding, and as the distances between the galaxies stretch, the light from them also stretches towards redder wavelengths.

We call this phenomena “redshift.” This means that for us, these objects can be quite dim at visible wavelengths, but bright at infrared ones. With a powerful enough infrared telescope, we can see these never-before-seen objects.

We can also study the atmospheres of planets orbiting other stars. Many of the elements and molecules we want to study in planetary atmospheres have characteristic signatures in the infrared.

Because infrared light comes from objects that are warm, in order to detect the super faint heat signals of things that are really, really far away, the telescope itself has to be very cold. How cold does the telescope have to be? Webb’s operating temperature is under 50K (or -370F/-223 C). As a comparison, water freezes at 273K (or 32 F/0 C).

How do we keep the telescope that cold?

Because there is no atmosphere in space, as long as you can keep something out of the Sun, it will get very cold. So Webb, as a whole, doesn’t need freezers or coolers - instead it has a giant sunshield that keeps it in the shade. (We do have one instrument on Webb that does have a cryocooler because it needs to operate at 7K.)

Also, we have to be careful that no nearby bright things can shine into the telescope – Webb is so sensitive to faint infrared light, that bright light could essentially blind it. The sunshield is able to protect the telescope from the light and heat of the Earth and Moon, as well as the Sun.

Out at what we call the Second Lagrange point, where the telescope will orbit the Sun in line with the Earth, the sunshield is able to always block the light from bright objects like the Earth, Sun and Moon.

How do we make sure it all works in space?

By lots of testing on the ground before we launch it. Every piece of the telescope was designed to work at the cold temperatures it will operate at in space and was tested in simulated space conditions. The mirrors were tested at cryogenic temperatures after every phase of their manufacturing process.

The instruments went through multiple cryogenic tests at our Goddard Space Flight Center in Maryland.

Once the telescope (instruments and optics) was assembled, it even underwent a full end-to-end test in our Johnson Space Center’s giant cryogenic chamber, to ensure the whole system will work perfectly in space.

What’s next for Webb?

It will move to Northrop Grumman where it will be mated to the sunshield, as well as the spacecraft bus, which provides support functions like electrical power, attitude control, thermal control, communications, data handling and propulsion to the spacecraft.