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How to Build a More Resilient Brain

Your executive control center has helped your mental health survive the pandemic thus far. Here’s how to strengthen it for the future.

A Lot has been written (including by this reporter) about the mental health toll of the pandemic, and for good reason. The latest numbers from the National Pulse Survey, a weekly mental health screen conducted by the National Center for Health Statistics and the U.S. Census Bureau, estimate that nearly 40% of Americans are currently experiencing symptoms of either anxiety or depression, a 50% increase over pre-pandemic times.

In some ways, though, it’s surprising that this number isn’t even higher given the stress, trauma, loss, and loneliness of the past year. The vast majority of people have spent the last 12 months locked inside their homes, terrified of catching a deadly virus, and trying not to kill their spouse, children, or roommates — in more ways than one. People living alone have marked births, deaths, graduations, and layoffs with no one to hug but our pillows. And yet the majority of Americans seem to have made it through with their mental health still intact. How?

If the root of much of the mental illness that’s emerged during the pandemic is unrelenting chronic stress, the opposite is also true: Resilience to trauma lies in the ability to adapt positively to stress.

“Resilience is really this ability to bounce back in the face of adversity,” says Steven Southwick, MD, an emeritus professor of psychiatry at Yale University. “From a biological standpoint, it’s the ability to modulate and hopefully constructively harness the stress response.”

In the brain, resilience means protecting against many stress-induced changes, particularly in regard to the size, activity, and connectivity of the amygdala, hippocampus, and prefrontal cortex — the brain’s fear, memory and mood, and executive control centers, respectively.

How does one prevent these neural changes? Some of it is genetic — gene variants affect the levels and activity of circulating stress hormones, as well as the hormones that counteract them. But perhaps more importantly, behavioral interventions can also build resilience and serve as a buffer against stress for those important brain systems.

“Resilience is not an on-off switch,” says Deborah Marin, MD, a professor of psychiatry and director of the Mount Sinai Center for Stress, Resilience, and Personal Growth, which was launched in 2020 to help health care workers cope with pandemic stress. “Some people may be born with more resilience, there may be some genetic component there, but there’s a lot of environmental interaction at play — everything from poverty, access to health care, education, community support.”

Southwick has been studying resilience for decades, interviewing countless combat veterans and other trauma survivors with and without post-traumatic stress disorder. Based on these conversations, he, along with collaborator Dennis Charney, MD, dean of the Icahn School of Medicine at Mount Sinai, developed a rubric of 10 behaviors and traits that contribute to people’s resilience.

“We and many others believe that a big part of resilience is knowing how to regulate the stress response,” Southwick says. “Resilience, in many ways, is a set of skills that can be learned, and pretty much any of us can, to some significant degree, learn these skills.”

Several of these skills, along with a few other strategies, are outlined below, but the basic premise is to engage in activities that strengthen your brain’s executive control center (the prefrontal cortex) so that it doesn’t get overrun by the brain’s fear and arousal center (the amygdala) during times of stress.

Optimism and cognitive flexibility

Negative emotions — fear, anger, disgust — prepare the body to fight or to flee through activation of the sympathetic nervous system, which narrows people’s focus and restricts our behaviors to those actions. Positive emotions, on the other hand, lower arousal levels, broaden attention, and increase creativity, which helps people be more flexible in their thoughts and behaviors.

While some people are naturally more optimistic than others, you can train yourself to think more positively through the skill of cognitive reappraisal. During times of stress, this means seeing a threat not as an insurmountable problem but as a challenge to be solved. For example, many people have tried to see the bright side of the extra time spent at home during the pandemic, viewing it as an opportunity to learn a new skill or pick an old hobby back up. It doesn’t change the outcome of the pandemic, but it does make the best of a bad situation. Instead of being bored at home and lamenting the loss of your social life, you might have learned a new language or started playing the guitar again now that you have more free time.

Southwick calls this type of reframing “realistic optimism.” “The realistic optimist basically has a future-oriented attitude and the belief that things will turn out okay,” he says. “The realistic optimist actually tends to see as much of the negative information that a more pessimistic person might, but they don’t remain focused or glued to this negative perception, and they have the ability to rapidly disengage, particularly from those negative perceptions that are not solvable. And they tend to be pretty darn good at turning their attention to solvable problems.”

This type of cognitive flexibility is associated with activity in the prefrontal cortex, and stronger executive control from the region, particularly over the threat response triggered by the amygdala, is important for not letting stress and anxiety run wild. Chronic stress can damage the connection between the prefrontal cortex and the amygdala, taking the brakes off of the brain’s alarm system and potentially leading to anxiety and PTSD. Having a stronger prefrontal network that can protect against this negative effect of chronic stress may help support resilience.

Meditation

Another resilience strategy that exercises the prefrontal cortex is meditation, which can largely be thought of as a practice of attention. Every time your mind wanders while you meditate, it requires cognitive control exerted by your prefrontal cortex to bring it back to focusing on your breath. And just like working out your biceps will make them stronger, so will working out a brain region in this way. Activate an area enough times, and your neurons start to wire new connections there, making the thought process more automatic.

“Our brain structure is changing from moment to moment. It’s much more plastic than we ever thought; it’s like a muscle, you can strengthen it or weaken it,” Southwick says. “It’s called ‘use-dependent neuroplasticity’ — the more I practice accurately, the more my brain will respond, and it will be less effortful in the future.”

On a more immediate time scale, taking a few deep breaths in a moment of stress can turn on the parasympathetic nervous system — the counterpart to the fight-or-flight response — and start to undo some of the body’s stress response. Deep breathing also lowers levels of noradrenaline, a brain chemical that increases arousal, which is also released in response to stress.

Stress inoculation and facing your fears

You can also train your brain to handle stress better through exposure to smaller stressors, particularly early in life. Scientists call this stress inoculation: Just like exposure to a tiny amount of a virus will educate your immune system on how to respond to it better next time, learning how to deal with mild stressors teaches your brain how to handle bigger stressors later.

“There’s some evidence that exposure to chronic stress early in life can actually make you resilient to stress later in life. Like that initial experience changes your resilience capacity,” says James Herman, PhD, a professor of psychiatry and behavioral neuroscience at the University of Cincinnati and director of the Laboratory of Stress Neurobiology. “You have all of these stressors that are present all the time, but if you’re used to them, you become resilient to them. They can help you later on in life, and they might even be beneficial.”

Part of this process is facing your fears, which, again, involves the prefrontal cortex overcoming the alarm bells ringing from the amygdala.

“Fear is completely natural. It’s, in many ways, a signal or something that is warning us, it’s a guide,” Southwick says. “But if you allow fear to hang around too long, it might evolve into panic. And when someone’s panicked, there tends to be a flooding of noradrenaline to the prefrontal cortex, which has a tendency to take the prefrontal cortex offline, which means that I’m now operating much more via my amygdala because my prefrontal cortex is no longer inhibiting the amygdala to the same degree that it normally does.”

Practicing facing your fears in lower stakes situations teaches your brain how to maintain control during stressful scenarios so that fear doesn’t turn into panic and spiral out of control. This isn’t something you can magically do right now to help you deal with the rest of the pandemic, but as things quiet down, consider it to help build your resilience for the future. Maybe challenge yourself to sign up for a class you’ve been intimidated to take or speak up in a meeting if normally you stay silent. In clinical settings, facing your fears is called exposure therapy and is used to treat anxiety disorders, particularly phobias and PTSD. With it, you gradually build up your exposure to the thing you’re afraid of while practicing relaxation techniques to prevent your amygdala and sympathetic nervous system from running out of control. The goal is ultimately to desensitize yourself to your fear, but the therapy can help you learn how to remain calm in any stressful situation.

Exercise and sleep

Maintaining good physical health is also critical for your mental capabilities. If you’ve heard it once, you’ve heard it a million times: Exercise is one of the best things you can do for your brain. Physical activity helps the brain grow new connections between brain cells and maybe even new neurons themselves. Much of this growth takes place in, you guessed it, the prefrontal cortex, as well as in the hippocampus, an area involved in regulating mood and memory. The new growth can help offset the loss of connections that occurs in those regions with chronic stress. Exercise also boosts levels of the feel-good neurochemicals dopamine and serotonin, both of which are depleted in people with depression.

On the flip side, lack of sleep can exacerbate many of the problems seen in the brain with chronic stress. One study from 2019 showed that sleep deprivation can cause a decrease in activity in the prefrontal cortex, while the amygdala becomes more reactive after a poor night’s sleep. This shift in activity correlated with people’s feelings of anxiety.

Social support

A crucial resilience strengthener experts bring up again and again is social support. In many ways, social connection counters the stress response from the sympathetic nervous system. Being with a friend or family member, especially during a stressful situation, dampens the activity of noradrenaline and cortisol. It also activates the reward center of the brain, providing a boost in dopamine.

“Human beings have many, many sources of resilience, but I think the most important is our relationships and social support and the way that we can help each other,” says Ann Masten, PhD, a psychologist and professor of child development at the University of Minnesota. “Feelings of belonging and support are powerful protective factors for many different kinds of situations.”

This aspect of resilience can be tricky during a pandemic when physical distancing from people outside of your household is necessary for safety. However, just knowing you have people in your corner who love and support you‚ even if you can’t currently be with them, still has a protective effect.

“The perception that you have others you can count on, even if they’re not presently there, has been shown to buffer some of the physiological effects [of stress],” says Julianne Holt-Lunstad, PhD, a professor of psychology and neuroscience at Brigham Young University. “[We’ve shown that] people who simply have more supportive people in their social network are less cardiovascularly reactive to a stressor task. Other studies have shown that even just thinking about someone who is very supportive is enough to buffer some of those physiological responses.”

Purpose and self-efficacy

Another key protective factor is having a sense of purpose and not feeling like you’re helpless in the stressful situation you’re facing. Similar to cognitive reappraisal, viewing the stressful scenario as an opportunity and that you have something to contribute provides a powerful sense of self-efficacy, which can prevent people from despairing. Scientists have known for decades that a feeling of helplessness is strongly tied to the development of depression, while having a sense of control is linked to resilience.

This factor is particularly relevant for frontline health care workers who have seen some of the greatest trauma during the pandemic. While roughly half of doctors, nurses, and other hospital staff are understandably experiencing depression, PTSD, and anxiety as a consequence, the other half have remained resilient. One reason may be because they can directly impact the course of the pandemic and have the ability to save people’s lives.

“Even if you’re working really hard, [if you’re] able to feel that your work has a sense of meaning and purpose, and that sense of meaning and purpose is aligned and shared by your colleagues and your institution, then you can tolerate an incredible amount of stress,” says Ronald Epstein, MD, a professor of family medicine at the University of Rochester Medical Center who has studied physician burnout.

If you’re not a frontline worker, it may be a little harder to feel like you have a role to play or any control over the situation. However, just because you can’t change the larger course of the pandemic doesn’t mean that you can’t take steps to control your own risk and the day-to-day unfolding of your life within it. Staying home for a year and forgoing social interactions and a normal life has been hard on everyone, but keep in mind that you’re doing it for a really important purpose — you’re potentially saving a life, maybe even your own. Every time you wear a mask, you’re taking your health into your own hands. Even just making and sticking to a daily schedule that slots in exercise or meditation can give you back some semblance of control.

“The pandemic and catastrophes like this can give you a sense that everything is out of control,” Masten says. “We don’t have a lot of control over what’s happening at a global level, but in our own lives, day by day, we can plan, take things one step at a time, and we can give ourselves a sense of accomplishment just in daily planning and setting manageable goals that provide us with a sense of self-efficacy.”

Preparation

Another reason that there isn’t more mental illness among health care workers is that they’ve trained for these types of situations. If someone was pulled off the street to work a day in the intensive care unit, their stress levels would go through the roof and they could very quickly become overwhelmed by the pressure and high stakes of the work, not to mention being exposed to so much suffering and death. But health care workers deal with this every day as part of their jobs.

Notably, many of the health care workers who did develop symptoms of depression or anxiety said that they had been transferred to a different department during the pandemic. In other words, they wound up doing a job that they had not been trained for. For example, nurses and doctors who normally work in rehabilitation were redeployed to the intensive care unit, where they saw much more death than they were used to. Some health care workers had to use ventilators for the first time since graduating from medical school, a skill they may not have felt as competent at.

“Redeployment was definitely a factor that contributed to having more symptomatology, either depression or anxiety or PTSD,” says Marin, the Mount Sinai psychiatrist who directs the Center for Stress, Resilience, and Personal Growth. “That probably is because when you’re redeployed, you’re doing a new skill set that you haven’t been doing or you’re used to, and you’re removed from an environment that may have your own community resilience.”

Virtually no one was prepared for the pandemic and all that it threw at us (how could you be?), and many people — and systems — broke down as a result. But there are at least lessons to be learned should disaster strike again in the future. Perhaps you still have a cache of beans and toilet paper stocked away that can give you a little peace of mind if there’s another stress on grocery store chains. Maybe you finally got to know your neighbors, and now you know who on your street might need a little more help getting groceries, or who has kids around the same age as yours. Or if your pandemic hobby was gardening or hiking or spending more time outdoors, maybe you developed some new survival or self-sufficiency skills you can keep in your back pocket to feel a little more competent and confident going forward.

Hopefully, government and institutions have also learned how to better support under-resourced groups, including parents, the elderly, and the unemployed. “I think this pandemic is a wake-up call for a lot of disasters that probably are going to come in the future, either other pandemics or climate disasters related to weather,” says Masten. “I think we need to think about how do we organize work and cities, and how do we support families with enough child care and financial support to give us flexibility?” These are big complicated questions, but many organizations, particularly those focused on public health, are starting to ask them, which is an important first step.

The past year has turned our lives upside down. People have lost loved ones, jobs, social lives, and any sense of normalcy. It’s entirely understandable, and even expected, that living through a year of a deadly pandemic would take a toll on mental health. But it’s also important to remember that depression, anxiety, and PTSD aren’t an inevitable result, although it does take some work to protect against them.

“As humans, we have this immense capacity to get through transient stresses,” Epstein says. “That’s why humans have survived — we’re not physically strong creatures, and we don’t have a lot of natural protection, so we rely on our ability to adapt to different circumstances.”

Epstein, who leads resilience workshops for health care workers, advises people to embed small habits into their day that can help relieve their stress, at least temporarily. This could be a five-minute meditation or breathing exercise when you feel yourself getting worked up; a quick walk around the block every day at lunch; a standing text or phone check-in with a friend; or a daily gratitude list you make at bedtime.

“Try to find something really, really small that you can do every day that will improve your own sense of positive potential, gratitude, community presence, your ability to be attentive — something that will actually make you feel a bit more aware and in control of your own inner life,” he says. “There’s a whole catalog of things that people can do that are awfully simple, easily accomplished, and doable, it’s just a question of reminding yourself and making that commitment.”

It’s also important to keep in mind that you don’t have to go through this alone. Again, social support is one of the most beneficial factors when it comes to resilience, so reach out to a friend or colleague if you’re struggling — they probably need to talk just as much as you do.

“Yes, we each can take actions, we each can be optimistic or practice meditation by ourselves to help deal with trauma. But a lot of the capacity for human resilience comes from the ways we interact with each other in relationships, in our friendships, in our congregating in cultural practices,” says Masten. “Human beings have a lot of capabilities to come up with ideas and share them of how to deal with whatever current issues are coming up with the pandemic or other kinds of struggles.”

She continues, “We’re great at ingenuity, and you can see […] as the challenges unfold, the mobilization unfolding at the same time. We respond when we’re challenged.”

By Dana G Smith Ph.D., (Medium). Illustration: Carolyn Figel

New discovery could be a major advance for understanding neurological diseases

The discovery of a new mechanism that controls the way nerve cells in the brain communicate with each other to regulate our learning and long-term memory could have major benefits to understanding how the brain works and what goes wrong in neurodegenerative disorders such as epilepsy and dementia. The breakthrough, published in Nature Neuroscience, was made by scientists at the University of Bristol and the University of Central Lancashire.   The findings will have far-reaching implications in many aspects of neuroscience and understanding how the brain works.

The human brain contains around 100-billion nerve cells, each of which makes about 10,000 connections to other cells, called synapses. Synapses are constantly transmitting information to, and receiving information from other nerve cells. A process, called long-term potentiation (LTP), increases the strength of information flow across synapses. Lots of synapses communicating between different nerve cells form networks and LTP intensifies the connectivity of the cells in the network to make information transfer more efficient. This LTP mechanism is how the brain operates at the cellular level to allow us to learn and remember. However, when these processes go wrong they can lead to neurological and neurodegenerative disorders.

Precisely how LTP is initiated is a major question in neuroscience. Traditional LTP is regulated by the activation of special proteins at synapses called NMDA receptors. This study, by Professor Jeremy Henley and co-workers reports a new type of LTP that is controlled by kainate receptors.

This is an important advance as it highlights the flexibility in the way synapses are controlled and nerve cells communicate. This, in turn, raises the possibility of targeting this new pathway to develop therapeutic strategies for diseases like dementia, in which there is too little synaptic transmission and LTP, and epilepsy where there is too much inappropriate synaptic transmission and LTP.

Jeremy Henley, Professor of Molecular Neuroscience in the University’s School of Biochemistry in the Faculty of Biomedical Sciences, said: “These discoveries represent a significant advance and will have far-reaching implications for the understanding of memory, cognition, developmental plasticity and neuronal network formation and stabilisation. In summary, we believe that this is a groundbreaking study that opens new lines of inquiry which will increase understanding of the molecular details of synaptic function in health and disease.”

Dr Milos Petrovic, co-author of the study and Reader in Neuroscience at the University of Central Lancashire added: “Untangling the interactions between the signal receptors in the brain not only tells us more about the inner workings of a healthy brain, but also provides a practical insight into what happens when we form new memories. If we can preserve these signals it may help protect against brain diseases.

“This is certainly an extremely exciting discovery and something that could potentially impact the global population. We have discovered potential new drug targets that could help to cure the devastating consequences of dementias, such as Alzheimer’s disease. Collaborating with researchers across the world in order to identify new ways to fight disease like this is what world-class scientific research is all about, and we look forward to continuing our work in this area.”

Lava flows like these Hawaii’an ones are endlessly mesmerizing. This type of flow is gravity-driven; rather than being pushed by explosive pressure, the lava flows under its own weight and that of the lava upstream. In fact, fluid dynamicists refer to this kind of flow as a gravity current, a term also applied to avalanches, turbidity currents, and cold drafts that sneak under your door in the wintertime. How quickly these viscous flows spread depends on factors like the density and viscosity of the lava and on the volume of lava being released at the vent. As the lava cools, its viscosity increases rapidly, and an outer crust can solidify while molten lava continues to flow beneath. Be sure to check out the full video below for even more gorgeous views of lava.  (Image/video credit: J. Tarsen, source; via J. Hertzberg)

Hold a buoyant sphere like a ping pong ball underwater and let it go, and you’ll find that the ball pops up out of the water. Intuitively, you would think that letting the ball go from a lower depth would make it pop up higher – after all, it has a greater distance to accelerate over, right? But it turns out that the highest jumps comes from balls that rise the shortest distance. When released at greater depths, the buoyant sphere follows a path that swerves from side to side. This oscillating path is the result of vortices being shed off the ball, first on one side and then the other. (Image and research credit: T. Truscott et al.)

Dead Poets Society (1989)

New ways to mass produce human neurons for studying neuropsychiatric disorders

Scientists from Singapore have streamlined the process of using human stem cells to mass produce GABAergic neurons (GNs) in the laboratory. This new protocol provides scientists with a robust source of GNs to study many psychiatric and neurological disorders such as autism, schizophrenia, and epilepsy, which are thought to develop at least in part due to GN dysfunction.

GNs are inhibitory neurons that reduce neuronal activation, and make up roughly 20 per cent of the human brain. They work alongside excitatory neurons (ENs) to ensure balanced neural activity for normal brain function. The coordinated interplay between GNs and ENs orchestrate specific activation patterns in the brain, which are responsible for our behaviour, emotions, and higher reasoning. Functional impairment of GNs results in imbalanced neural activity, thereby contributing to the symptoms observed in many psychiatric disorders.

The availability of high quality, functional human GN populations would facilitate the development of good models for studying psychiatric disorders, as well as for screening drug effects on specific populations of neurons. Scientists worldwide have been hard at work trying to generate a consistent supply of GNs in the laboratory, but have been faced with many challenges. Protocols involving multiple complex stages, poor yield, and requiring a long time to generate mature and functional GNs are just some of the limitations encountered.

Many of these limitations have now been overcome by the development of a rapid and robust protocol to generate GNs from human pluripotent stem cells (hPSCs) in a single step. With the addition of a specific combination of factors, hPSCs turn into mature and functional GNs in a mere six – eight weeks. This is about two – three times faster than the 10 - 30 weeks required for previous protocols. In addition, this new protocol is highly efficient, with GNs making up more than 80 per cent of the final neuron population.

To develop this protocol, the team from Duke-NUS Medical School (Duke-NUS), A*STAR’s Genome Institute of Singapore (GIS) and the National Neuroscience Institute (NNI) first identified genetic factors involved in GN development in the brain. The team then tried many different combinations of these factors, and succeeded in confirming that mature and functional human GNs were indeed generated.

“Just like how a balance of Yin and Yang is needed in order to stay healthy, a balance of ENs and GNs is required for normal brain function. We now know a fair bit about ENs because we have good protocols to make them. However, we still know very little of the other player, the GNs, because current protocols do not work well. Yet, when these GNs malfunction our brain goes haywire,” commented Dr Alfred Sun, a Research Fellow at NNI and co-first author of the publication alongside Mr Qiang Yuan, an NUS Graduate School PhD student.

“Our quick, efficient and easy way to mass produce GNs for lab use is a game changer for neuroscience and drug discovery. With increased recognition of the essential role of GNs in almost all neurological and psychiatric diseases, we envisage our new method to be widely used to advance research and drug screening,” said Dr Shawn Je, Assistant Professor in the Neuroscience and Behavioural Disorders Programme at Duke-NUS, and senior author of the study.

The speed and efficiency of generating GNs with this new protocol provides researchers unprecedented access to the quantities of neurons necessary for studying the role of GNs in disease mechanisms. Drugs and small molecules may now be screened at an unparalleled rate to discover the next blockbuster treatment for autism, schizophrenia, and epilepsy.

Woahh!!!

The Application of Sunblock in Visible and UV Light. 

(lifepixel)

Fluid systems can sometimes serve as analogs for other physical phenomena. For example, bouncing droplets can recreate quantum effects and a hydraulic jump can act like a white hole. In this work, a bathtub vortex serves as an analog for a rotating black hole, a system that’s extremely difficult to study under normal circumstances. In theory, the property of superradiance makes it possible for gravitational waves to extract energy from a rotating black hole, but this has not yet been observed. A recent study has, however, observed superradiance for the first time in this fluid analog.

To do this, the researchers set up a vortex draining in the center of a tank. (Water was added back at the edges to keep the depth constant.) This served as their rotating black hole. Then they generated waves from one side of the tank and observed how those waves scattered off the vortex. The pattern you see on the water surface in the top image is part of a technique used to measure the 3D surface of the water in detail, which allowed the researchers to measure incoming and scattered waves around the vortex. For superradiance to occur, scattered waves had to be more energetic after interacting with the vortex than they were before, which is exactly what the researchers found. Now that they’ve observed superradiance in the laboratory, scientists hope to probe the process in greater detail, which will hopefully help them observe it in nature as well. For more on the experimental set-up, see Sixty Symbols, Tech Insider UK, and the original paper. (Image credit: Sixty Symbols, source; research credit: T. Torres et al., pdf; via Tech Insider UK)