Useful :)

Check out this 1890s advertisement for cowpox vaccines sold by Lancaster County Vaccine Farms. The advertisement was published as part of the 1893 volume of Polk’s Medical and Surgical Register of the United States.

Dublin streetscapes from 1900 (John J. Clarke collection) 

My boyfriend, @inlove-with-a-spine, is very uninformed about Southeast Asian fruits (he only knows durian) which inspired me to find these online.

I’m pretty sure the names are different in other Southeast Asian countries, though.

From left to right (in Indonesian):

Duku

Jambu monyet

Jeruk

Lengkeng

Kedondong

Manggis

Rambutan

Nangka

Salak

Sawo

Man with quadriplegia employs injury bridging technologies to move again—just by thinking

First recipient of implanted brain-recording and muscle-stimulating systems reanimates limb that had been stilled for eight years

Bill Kochevar grabbed a mug of water, drew it to his lips and drank through the straw.

His motions were slow and deliberate, but then Kochevar hadn’t moved his right arm or hand for eight years.

And it took some practice to reach and grasp just by thinking about it.

Kochevar, who was paralyzed below his shoulders in a bicycling accident, is believed to be the first person with quadriplegia in the world to have arm and hand movements restored with the help of two temporarily implanted technologies.

A brain-computer interface with recording electrodes under his skull, and a functional electrical stimulation (FES) system* activating his arm and hand, reconnect his brain to paralyzed muscles.

Holding a makeshift handle pierced through a dry sponge, Kochevar scratched the side of his nose with the sponge. He scooped forkfuls of mashed potatoes from a bowl—perhaps his top goal—and savored each mouthful.

“For somebody who’s been injured eight years and couldn’t move, being able to move just that little bit is awesome to me,” said Kochevar, 56, of Cleveland. “It’s better than I thought it would be.”

Kochevar is the focal point of research led by Case Western Reserve University, the Cleveland Functional Electrical Stimulation (FES) Center at the Louis Stokes Cleveland VA Medical Center and University Hospitals Cleveland Medical Center (UH). A study of the work was published in the The Lancet March 28 at 6:30 p.m. U.S. Eastern time.

“He’s really breaking ground for the spinal cord injury community,” said Bob Kirsch, chair of Case Western Reserve’s Department of Biomedical Engineering, executive director of the FES Center and principal investigator (PI) and senior author of the research. “This is a major step toward restoring some independence.”

When asked, people with quadriplegia say their first priority is to scratch an itch, feed themselves or perform other simple functions with their arm and hand, instead of relying on caregivers.

“By taking the brain signals generated when Bill attempts to move, and using them to control the stimulation of his arm and hand, he was able to perform personal functions that were important to him,” said Bolu Ajiboye, assistant professor of biomedical engineering and lead study author.

Technology and training

The research with Kochevar is part of the ongoing BrainGate2* pilot clinical trial being conducted by a consortium of academic and VA institutions assessing the safety and feasibility of the implanted brain-computer interface (BCI) system in people with paralysis. Other investigational BrainGate research has shown that people with paralysis can control a cursor on a computer screen or a robotic arm (braingate.org).

“Every day, most of us take for granted that when we will to move, we can move any part of our body with precision and control in multiple directions and those with traumatic spinal cord injury or any other form of paralysis cannot,” said Benjamin Walter, associate professor of neurology at Case Western Reserve School of Medicine, clinical PI of the Cleveland BrainGate2 trial and medical director of the Deep Brain Stimulation Program at UH Cleveland Medical Center.

“The ultimate hope of any of these individuals is to restore this function,” Walter said. “By restoring the communication of the will to move from the brain directly to the body this work will hopefully begin to restore the hope of millions of paralyzed individuals that someday they will be able to move freely again.”

Jonathan Miller, assistant professor of neurosurgery at Case Western Reserve School of Medicine and director of the Functional and Restorative Neurosurgery Center at UH, led a team of surgeons who implanted two 96-channel electrode arrays—each about the size of a baby aspirin—in Kochevar’s motor cortex, on the surface of the brain.

The arrays record brain signals created when Kochevar imagines movement of his own arm and hand. The brain-computer interface extracts information from the brain signals about what movements he intends to make, then passes the information to command the electrical stimulation system.

To prepare him to use his arm again, Kochevar first learned how to use his brain signals to move a virtual-reality arm on a computer screen.

“He was able to do it within a few minutes,” Kirsch said. “The code was still in his brain.”

As Kochevar’s ability to move the virtual arm improved through four months of training, the researchers believed he would be capable of controlling his own arm and hand.

Miller then led a team that implanted the FES systems’ 36 electrodes that animate muscles in the upper and lower arm.

The BCI decodes the recorded brain signals into the intended movement command, which is then converted by the FES system into patterns of electrical pulses.

The pulses sent through the FES electrodes trigger the muscles controlling Kochevar’s hand, wrist, arm, elbow and shoulder. To overcome gravity that would otherwise prevent him from raising his arm and reaching, Kochevar uses a mobile arm support, which is also under his brain’s control.

New Capabilities

Eight years of muscle atrophy required rehabilitation. The researchers exercised Kochevar’s arm and hand with cyclical electrical stimulation patterns. Over 45 weeks, his strength, range of motion and endurance improved. As he practiced movements, the researchers adjusted stimulation patterns to further his abilities.

Kochevar can make each joint in his right arm move individually. Or, just by thinking about a task such as feeding himself or getting a drink, the muscles are activated in a coordinated fashion.

When asked to describe how he commanded the arm movements, Kochevar told investigators, “I’m making it move without having to really concentrate hard at it…I just think ‘out’…and it goes.”

Kocehvar is fitted with temporarily implanted FES technology that has a track record of reliable use in people. The BCI and FES system together represent early feasibility that gives the research team insights into the potential future benefit of the combined system.

Advances needed to make the combined technology usable outside of a lab are not far from reality, the researchers say. Work is underway to make the brain implant wireless, and the investigators are improving decoding and stimulation patterns needed to make movements more precise. Fully implantable FES systems have already been developed and are also being tested in separate clinical research.

Kochevar welcomes new technology—even if it requires more surgery—that will enable him to move better. “This won’t replace caregivers,” he said. “But, in the long term, people will be able, in a limited way, to do more for themselves.”

The investigational BrainGate technology was initially developed in the Brown University laboratory of John Donoghue, now the founding director of the Wyss Center for Bio and Neuroengineering in Geneva, Switzerland. The implanted recording electrodes are known as the Utah array, originally designed by Richard Normann, Emeritus Distinguished Professor of Bioengineering at the University of Utah.

The report in Lancet is the result of a long-running collaboration between Kirsch, Ajiboye and the multi-institutional BrainGate consortium. Leigh Hochberg, a neurologist and neuroengineer at Massachusetts General Hospital, Brown University and the VA RR&D Center for Neurorestoration and Neurotechnology in Providence, Rhode Island, directs the pilot clinical trial of the BrainGate system and is a study co-author.

“It’s been so inspiring to watch Mr. Kochevar move his own arm and hand just by thinking about it,” Hochberg said. “As an extraordinary participant in this research, he’s teaching us how to design a new generation of neurotechnologies that we all hope will one day restore mobility and independence for people with paralysis.”

Japan’s annual Wara Art Festival (previously featured here), one of our favorite signs that autumn has returned, is now underway at Uwasekigata Park. “Wara” is the Japanese term for rice straw. It’s what remains after the rice harvest. Some regions use it to feed livestock or improve the soil. But in Niigata Prefecture it’s used to make these enormous sculptures.

The Wara Art Festival all started in 2006 when the local district reached out to Musashino Art University to seek guidance on transforming their abundant amount of rice straw into art. And in 2008, the very first Wara Art Festival was held. Since then, every year the school sends art students up to Niigata to assist in creating sculptures made out of rice straw. The festivities have ended but the sculptures are on display through October 31, 2017.

To mark the 10th anniversary of the Wara Art Festival participants made this year’s sculptures twice as big as usual.

Visit the Wara Art Festival Facebook page for more photos of these magnificent sculptures.

[via My Modern Met and Spoon & Tamago]

“We seem to be made to suffer. It’s our lot in life.” -C-3PO

List of medieval European scientists

Anthemius of Tralles (ca. 474 – ca. 534): a professor of geometry and architecture, authored many influential works on mathematics and was one of the architects of the famed Hagia Sophia, the largest building in the world at its time. His works were among the most important source texts in the Arab world and Western Europe for centuries after.

John Philoponus (ca. 490–ca. 570): also known as John the Grammarian, a Christian Byzantine philosopher, launched a revolution in the understanding of physics by critiquing and correcting the earlier works of Aristotle. In the process he proposed important concepts such as a rudimentary notion of inertia and the invariant acceleration of falling objects. Although his works were repressed at various times in the Byzantine Empire, because of religious controversy, they would nevertheless become important to the understanding of physics throughout Europe and the Arab world.

Paul of Aegina (ca. 625–ca. 690): considered by some to be the greatest Christian Byzantine surgeon, developed many novel surgical techniques and authored the medical encyclopedia Medical Compendium in Seven Books. The book on surgery in particular was the definitive treatise in Europe and the Islamic world for hundreds of years.

The Venerable Bede (ca. 672–735): a Christian monk of the monasteries of Wearmouth and Jarrow who wrote a work On the Nature of Things, several books on the mathematical / astronomical subject of computus, the most influential entitled On the Reckoning of Time. He made original discoveries concerning the nature of the tides and his works on computus became required elements of the training of clergy, and thus greatly influenced early medieval knowledge of the natural world.

Rabanus Maurus (c. 780 – 856): a Christian monk and teacher, later archbishop of Mainz, who wrote a treatise on Computus and the encyclopedic work De universo. His teaching earned him the accolade of "Praeceptor Germaniae," or "the teacher of Germany."

Abbas Ibn Firnas (810 – 887): a polymath and inventor in Muslim Spain, made contributions in a variety of fields and is most known for his contributions to glass-making and aviation. He developed novel ways of manufacturing and using glass. He broke his back at an unsuccessful attempt at flying a primitive hang glider in 875.

Pope Sylvester II (c. 946–1003): a Christian scholar, teacher, mathematician, and later pope, reintroduced the abacus and armillary sphere to Western Europe after they had been lost for centuries following the Greco-Roman era. He was also responsible in part for the spread of the Hindu-Arabic numeral system in Western Europe.

Maslamah al-Majriti (died 1008): a mathematician, astronomer, and chemist in Muslim Spain, made contributions in many areas, from new techniques for surveying to updating and improving the astronomical tables of al-Khwarizmi and inventing a process for producing mercury oxide.[citation needed] He is most famous, though, for having helped transmit knowledge of mathematics and astronomy to Muslim Spain and Christian Western Europe.

Abulcasis (936-1013): a physician and scientist in Muslim Spain, is considered to be the father of modern surgery. He wrote numerous medical texts, developed many innovative surgical instruments, and developed a variety of new surgical techniques and practices. His texts were considered the definitive works on surgery in Europe until the Renaissance.

Constantine the African (c. 1020&–1087): a Christian native of Carthage, is best known for his translating of ancient Greek and Roman medical texts from Arabic into Latin while working at the Schola Medica Salernitana in Salerno, Italy. Among the works he translated were those of Hippocrates and Galen.

Arzachel (1028–1087): the foremost astronomer of the early second millennium, lived in Muslim Spain and greatly expanded the understanding and accuracy of planetary models and terrestrial measurements used for navigation. He developed key technologies including the equatorium and universal latitude-independent astrolabe.

Avempace (died 1138): a famous physicist from Muslim Spain who had an important influence on later physicists such as Galileo. He was the first to theorize the concept of a reaction force for every force exerted.

Adelard of Bath (c. 1080 – c. 1152): was a 12th-century English scholar, known for his work in astronomy, astrology, philosophy and mathematics.

Avenzoar (1091–1161): from Muslim Spain, introduced an experimental method in surgery, employing animal testing in order to experiment with surgical procedures before applying them to human patients.[4] He also performed the earliest dissections and postmortem autopsies on both humans as well as animals.

Robert Grosseteste (1168–1253): Bishop of Lincoln, was the central character of the English intellectual movement in the first half of the 13th century and is considered the founder of scientific thought in Oxford. He had a great interest in the natural world and wrote texts on the mathematical sciences of optics, astronomy and geometry. In his commentaries on Aristotle's scientific works, he affirmed that experiments should be used in order to verify a theory, testing its consequences. Roger Bacon was influenced by his work on optics and astronomy.

Albert the Great (1193–1280): Doctor Universalis, was one of the most prominent representatives of the philosophical tradition emerging from the Dominican Order. He is one of the thirty-three Saints of the Roman Catholic Church honored with the title of Doctor of the Church. He became famous for his vast knowledge and for his defence of the pacific coexistence between science and religion. Albert was an essential figure in introducing Greek and Islamic science into the medieval universities, although not without hesitation with regard to particular Aristotelian theses. In one of his most famous sayings he asserted: "Science does not consist in ratifying what others say, but of searching for the causes of phenomena." Thomas Aquinas was his most famous pupil.

John of Sacrobosco (c. 1195 – c. 1256): was a scholar, monk, and astronomer (probably English, but possibly Irish or Scottish) who taught at the University of Paris and wrote an authoritative and influential mediaeval astronomy text, the Tractatus de Sphaera; the Algorismus, which introduced calculations with Hindu-Arabic numerals into the European university curriculum; the Compotus ecclesiasticis on Easter reckoning; and the Tractatus de quadrante on the construction and use of the astronomical quadrant.

Jordanus de Nemore (late 12th, early 13th century): was one of the major pure mathematicians of the Middle Ages. He wrote treatises on mechanics ("the science of weights"), on basic and advanced arithmetic, on algebra, on geometry, and on the mathematics of stereographic projection.

Villard de Honnecourt (fl. 13th century): a French engineer and architect who made sketches of mechanical devices such as automatons and perhaps drew a picture of an early escapement mechanism for clockworks.

Roger Bacon (1214–94): Doctor Admirabilis, joined the Franciscan Order around 1240 where, influenced by Grosseteste, Alhacen and others, he dedicated himself to studies where he implemented the observation of nature and experimentation as the foundation of natural knowledge. Bacon wrote in such areas as mechanics, astronomy, geography and, most of all, optics. The optical research of Grosseteste and Bacon established optics as an area of study at the medieval university and formed the basis for a continuous tradition of research into optics that went all the way up to the beginning of the 17th century and the foundation of modern optics by Kepler.[8]

Ibn al-Baitar (died 1248): a botanist and pharmacist in Muslim Spain, researched over 1400 types of plants, foods, and drugs and compiled pharmaceutical and medical encyclopedias documenting his research. These were used in the Islamic world and Europe until the 19th century.

Theodoric Borgognoni (1205-1296): was an Italian Dominican friar and Bishop of Cervia who promoted the uses of both antiseptics and anaesthetics in surgery. His written work had a deep impact on Henri de Mondeville, who studied under him while living in Italy and later became the court physician for King Philip IV of France.

William of Saliceto (1210-1277): was an Italian surgeon of Lombardy who advanced medical knowledge and even challenged the work of the renowned Greco-Roman surgeon Galen (129-216 AD) by arguing that allowing pus to form in wounds was detrimental to the health of he patient.

Thomas Aquinas (1227–74): Doctor Angelicus, was an Italian theologian and friar in the Dominican Order. As his mentor Albert the Great, he is a Catholic Saint and Doctor of the Church. In addition to his extensive commentaries on Aristotle's scientific treatises, he was also said to have written an important alchemical treatise titled Aurora Consurgens. However, his most lasting contribution to the scientific development of the period was his role in the incorporation of Aristotelianism into the Scholastic tradition.

Arnaldus de Villa Nova (1235-1313): was an alchemist, astrologer, and physician from the Crown of Aragon who translated various Arabic medical texts, including those of Avicenna, and performed optical experiments with camera obscura.

John Duns Scotus (1266–1308): Doctor Subtilis, was a member of the Franciscan Order, philosopher and theologian. Emerging from the academic environment of the University of Oxford. where the presence of Grosseteste and Bacon was still palpable, he had a different view on the relationship between reason and faith as that of Thomas Aquinas. For Duns Scotus, the truths of faith could not be comprehended through the use of reason. Philosophy, hence, should not be a servant to theology, but act independently. He was the mentor of one of the greatest names of philosophy in the Middle Ages: William of Ockham.

Mondino de Liuzzi (c. 1270-1326): was an Italian physician, surgeon, and anatomist from Bologna who was one of the first in Medieval Europe to advocate for the public dissection of cadavers for advancing the field of anatomy. This followed a long-held Christian ban on dissections performed by the Alexandrian school in the late Roman Empire.

William of Ockham (1285–1350): Doctor Invincibilis, was an English Franciscan friar, philosopher, logician and theologian. Ockham defended the principle of parsimony, which could already be seen in the works of his mentor Duns Scotus. His principle later became known as Occam's Razor and states that if there are various equally valid explanations for a fact, then the simplest one should be chosen. This became a foundation of what would come to be known as the scientific method and one of the pillars of reductionism in science. Ockham probably died of the Black Plague. Jean Buridan and Nicole Oresme were his followers.

Jacopo Dondi dell'Orologio (1290-1359): was an Italian doctor, clockmaker, and astronomer from Padua who wrote on a number of scientific subjects such as pharmacology, surgery, astrology, and natural sciences. He also designed an astronomical clock.

Richard of Wallingford (1292-1336): an English abbot, mathematician, astronomer, and horologist who designed an astronomical clock as well as an equatorium to calculate the lunar, solar and planetary longitudes, as well as predict eclipses.

Jean Buridan (1300–58): was a French philosopher and priest. Although he was one of the most famous and influent philosophers of the late Middle Ages, his work today is not renowned by people other than philosophers and historians. One of his most significant contributions to science was the development of the theory of impetus, that explained the movement of projectiles and objects in free-fall. This theory gave way to the dynamics of Galileo Galilei and for Isaac Newton's famous principle of Inertia.

Guy de Chauliac (1300-1368): was a French physician and surgeon who wrote the Chirurgia magna, a widely read publication throughout medieval Europe that became one of the standard textbooks for medical knowledge for the next three centuries. During the Black Death he clearly distinguished Bubonic Plague and Pneumonic Plague as separate diseases, that they were contagious from person to person, and offered advice such as quarantine to avoid their spread in the population. He also served as the personal physician for three successive popes of the Avignon Papacy.

John Arderne (1307-1392): was an English physician and surgeon who invented his own anesthetic that combined hemlock, henbane, and opium. In his writings, he also described how to properly excise and remove the abscess caused by anal fistula.

Nicole Oresme (c. 1323–82): was one of the most original thinkers of the 14th century. A theologian and bishop of Lisieux, he wrote influential treatises in both Latin and French on mathematics, physics, astronomy, and economics. In addition to these contributions, Oresme strongly opposed astrology and speculated about the possibility of a plurality of worlds.

Giovanni Dondi dell'Orologio (c. 1330-1388): was a clockmaker from Padua, Italy who designed the astarium, an astronomical clock and planetarium that utilized the escapement mechanism that had been recently invented in Europe. He also attempted to describe the mechanics of the solar system with mathematical precision.

the phrase “curiosity killed the cat” is actually not the full phrase it actually is “curiosity killed the cat but satisfaction brought it back” so don’t let anyone tell you not to be a curious little baby okay go and be interested in the world uwu

A whole lot of books

In 1610, after successfully rebuilding, reopening and firmly establishing the Bodleian Library, Sir Thomas Bodley made it his new goal to ensure the library’s long-term relevance. He forged an agreement with the Stationers’ Company that saw his library receive one copy of everything printed under royal license. This would guarantee that the Bodleian would continue to be at the cutting edge of literature and librarianship.

And this was when the Bodleian became, by effect, the first Legal Deposit library in the UK. From 1662, the notions were solidified and the Royal Library and the University Library of Cambridge were also party to the same privileges. Until the establishment of the British Library in 1753, the university libraries of Oxford and Cambridge - especially the Bodleian Library, which had enjoyed the legal deposit privilege the longest – served as the de facto national libraries of the United Kingdom.

But what’s the current state of Legal Deposit at the Bodleian? And, as @LowlandsLady asked us on Twitter, might it ever feel like a curse to have this multitude of books rolling into the library?

There’s nobody better to answer these questions than Jackie Raw, Head of Legal Deposit Operations in our Collections Management department. From this point on, this Tumblr post belongs to Jackie.

The Legal Deposit Libraries Act 2003 obliges publishers to deposit, at their own cost, one copy of every printed publication that is published or distributed in the UK with the British Library and, upon request, with up to five other Legal Deposit Libraries of which the Bodleian is one.

These Legal Deposit Libraries seek to ensure that the UK published output is preserved for posterity. To do this the requesting libraries together use the Agency for the Legal Deposit Libraries. The Agency makes claims for titles on our behalf and, on receipt, these are recorded and distributed weekly to the libraries. By collaborating the Legal Deposit Libraries seek to develop and co-ordinate national coverage and preservation of, and access to, publications acquired by legal deposit.

A random selection of books arriving by Legal Deposit.

While the Legal Deposit system has existed in various forms since 1662, the reformed Act in 2003 extended the provision for printed material to cover non-print works. This brings new and emerging publishing media under its scope. The Regulations for this came into force in April 2013. We now have the opportunity to add e-books, e-journals, digital maps and digital music scores to our collections and to harvest and archive content from UK-published material on UK websites under the new legislation.

Again the libraries are working together to ensure coverage. The benefits of holding a collection of over 12 million physical items, much of which has been deposited under Legal Deposit, and a growing digital collection cannot be overstated.

A recent count of books arriving daily at the Bodleian Libraries.

Legal Deposit ensures the nation’s heritage is collected systematically and preserved for posterity. It supports and advances the teaching and research activities of the University of Oxford and national and international scholarship more widely by collecting, recording and making available this material and it provides, in a cost-effective way, access to a wide range of publications many of which are unlikely to be found outside of the Legal Deposit system.

However, it is also a responsibility.

Clearly there can be pressures on space, storage and transportation. There are staff levels and processing costs to consider and issues around funding limitations. On the other hand there is provision within the Act to allow libraries, other than the British Library, to be selective in what we acquire. So, by consulting and collaborating we aim to ensure as complete coverage as possible within resourcing limits without overburdening any one library with the rate at which our collections are growing.

It’s easy:  Form a triangle, then a hexagon, then a bicycle wheel

This is the general mechanism on how a spider spins its web (talk about engineering, right?). When an insect gets caught in its web, the vibrations caused by the insect is felt by the spider which then rushes to engulf its prey.

Now here is the trippy part ; This is the effect of drugs on the pattern of the web.

Hope you are having a great week. Have a good one!

* Spider spinning a web (video) (if you find a better full video let us know)

** Spiders on drugs -  NASA article ; Video