The Phrase “curiosity Killed The Cat” Is Actually Not The Full Phrase It Actually Is “curiosity

Beautiful Blaschka glass model of a Glaucus sea slug.

These amazing animals can give a painful sting if handled. This is because they feed on colonial cnidarians such as Portuguese man o’ war and store the venomous nematocysts of their prey for self-protection.

The Blood Of Dragons Could Destroy Antibiotic Resistance

Antibiotic resistance is one of the most pressing problems of our times. Traditional antimicrobial drugs aren’t working the way they used to, and the rise

Antibiotic resistance is one of the most pressing problems of our times. Traditional antimicrobial drugs aren’t working the way they used to, and the rise of “superbugs” could bring about the post-antibiotic age, where easily treatable infections suddenly become life-threatening incurable illnesses.

There have been a slew of new discoveries recently that have revealed brand new ways to turn the tide, but the latest revelation at the hands of a team from George Mason University is a particularly unusual sounding one. As it turns out, we could use the blood of dragons to annihilate superbugs.

No, this isn’t an analogy or a plot line from Game of Thrones. The devil-toothed Komodo dragon – the devious beast from Indonesia – has a particular suite of chemical compounds in its blood that’s pure anathema to a wide range of bacteria.

They’re known as CAMPs – cationic antimicrobial peptides – and although plenty of living creatures (including humans) have versions of these, Komodo dragons have 48, with 47 of them being powerfully antimicrobial. The team managed to cleverly isolate these CAMPs in a laboratory by using electrically-charged hydrogels – strange, aerated substances – to suck them out of the dragons’ blood samples.

Synthesizing their own versions of eight of these CAMPs, they put them up against two strains of lab-grown “superbugs,” MRSA and Pseudomona aeruginosa, to see if they had any effect. Remarkably, all eight were able to kill the latter, whereas seven of them destroyed all trace of both, doing something that plenty of conventional antibiotic drugs couldn’t.

Writing in the Journal of Proteome Research, the researchers write that these powerful CAMPs explain why Komodo dragons are able to contain such a dense, biodiverse population of incredibly dangerous bacteria in their mouths. Although it’s not clear where all these bacteria originally came from, the chemical compounds in their blood ensures that they’ll never be properly infected.

In fact, it was this ability to co-exist with such lethal bacteria that piqued the interest of the researchers in the first place.

“Komodo dragon serum has been demonstrated to have in vitro antibacterial properties,” they note. “The role that CAMPs play in the innate immunity of the Komodo dragon is potentially very informative, and the newly identified Komodo dragon CAMPs may lend themselves to the development of new antimicrobial therapeutics.”

It’ll be awhile before these CAMPs are tested in human trials, but the idea that we’re effectively using dragon’s blood, or plasma, to fight against resurgent diseases is genuinely quite thrilling. Alongside Hulk-like drugs that physically rip bacteria apart, there’s a chance that, with the help of these legendary lizards, we may win this war yet.

The math trick that college will never teach you! : Parametric Integration

Parametric integration is one such technique that once you are made aware of it, you will never for the love of god forget it. It goes by many names : ‘Differentiation under the Integral sign’, ‘Feynman’s famous trick’ , ‘Parametric Integration’ and so on.

Let me demonstrate :

Now this integral might seem familiar to you if you have taken a calculus course before and to evaluate it is rather simple as well.

Knowing this you can do lots of crazy stuff. Lets differentiate this expression wrt to the parameter in the integral – s (Hence the name parametric integration ). i.e 

Look at that, by simple differentiation we have obtained the expression for another integral. How cool is that! It gets even better.

Lets differentiate it once more: 

.

.

.

If you keep on differentiating the expression n times, one gets this : 

Now substituting the value of s to be 1, we obtain the following integral expression for the factorial. This is known as the gamma function.

There are lots of ways to derive the above expression for the gamma function, but parametric integration is in my opinion the most subtle way to arrive at it. :D

This is a really powerful technique and I strong suggest that if you have taken calculus, then please do read this article.

Have a great day!

EDIT:  It had to be gamma(n+1) not gamma(n) .Thank you @mattchelldavis

初代「ゴジラ」俳優、中島春雄さん死去 http://www.bbc.com/japanese/40860452

The code that took America's Apollo 11  to the moon in the 1960's has been published

When programmers at the MIT Instrumentation Laboratory set out to develop the flight software for the Apollo 11 space program in the mid-1960s, the necessary technology did not exist. They had to invent it.

They came up with a new way to store computer programs, called “rope memory,” and created a special version of the assembly programming language. Assembly itself is obscure to many of today’s programmers—it’s very difficult to read, intended to be easily understood by computers, not humans. For the Apollo Guidance Computer (AGC), MIT programmers wrote thousands of lines of that esoteric code.

Here’s a very 1960s data visualization of just how much code they wrote—this is Margaret Hamilton, director of software engineering for the project, standing next to a stack of paper containing the software:

The AGC code has been available to the public for quite a while–it was first uploaded by tech researcher Ron Burkey in 2003, after he’d transcribed it from scanned images of the original hardcopies MIT had put online. That is, he manually typed out each line, one by one.

“It was scanned by an airplane pilot named Gary Neff in Colorado,” Burkey said in an email. “MIT got hold of the scans and put them online in the form of page images, which unfortunately had been mutilated in the process to the point of being unreadable in places.” Burkey reconstructed the unreadable parts, he said, using his engineering skills to fill in the blanks.

  “Quite a bit later, I managed to get some replacement scans from Gary Neff for the unreadable parts and fortunately found out that the parts I filled in were 100% correct!” he said.

As enormous and successful as Burkey’s project has been, however, the code itself remained somewhat obscure to many of today’s software developers. That was until last Thursday (July 7), when former NASA intern Chris Garry uploaded the software in its entirety to GitHub, the code-sharing site where millions of programmers hang out these days.

Within hours, coders began dissecting the software, particularly looking at the code comments the AGC’s original programmers had written. In programming, comments are plain-English descriptions of what task is being performed at a given point. But as the always-sharp joke detectives in Reddit’s r/ProgrammerHumor section found, many of the comments in the AGC code go beyond boring explanations of the software itself. They’re full of light-hearted jokes and messages, and very 1960s references.

One of the source code files, for example, is called BURN_BABY_BURN--MASTER_IGNITION_ROUTINE, and the opening comments explain why:

About 900 lines into that subroutine, a reader can see the playfulness of the original programming team come through, in the first and last comments in this block of code:

In the file called LUNAR_LANDING_GUIDANCE_EQUATIONS.s, it appears that two lines of code were  meant to be temporary ended up being permanent, against the hopes of one programmer:

In the same file, there’s also code that appears to instruct an astronaut to “crank the silly thing around.”

“That code is all about positioning the antenna for the LR (landing radar),” Burkey explained. “I presume that it’s displaying a code to warn the astronaut to reposition it.”

And in the PINBALL_GAME_BUTTONS_AND_LIGHTS.s file, which is described as “the keyboard and display system program … exchanged between the AGC and the computer operator,” there’s a peculiar Shakespeare quote:

This is likely a reference to the AGC programming language itself, as one Reddit user . The language used predetermined “nouns” and “verbs” to execute operations. The verb pointed out 37, for example, means “Run program,” while the noun 33 means “Time to ignition.”

Now that the code is on GitHub, programmers can actually suggest changes and file issues. And, of course, they have

Vintage postcards showing women taking sand baths in hot springs city of Beppu pre WW2 (seen on). Sunayu are still done today (and it’s great!)

Staff Pick of the Week

As a lover of mythology and folklore, my first staff pick is The Wonder-Smith and His Son, by Ella Young (1867-1956), with illustrations by Boris Artzybasheff (1899-1965). It was published by Longmans, Green Co. in 1927 and was a Newbery Honor recipient in 1928. The book is a collection of myths from Ireland and Scotland about a legendary wonder smith known as the Gubbaun Saor, a “maker of worlds and a shaper of universes.” There are fourteen stories in the collection, detailing how the Gubbaun Saor got his world-building abilities, which involved finding a bag of magical tools that were dropped from the sky by a bird. The book also includes tales about his adopted son Lugh and his daughter Aunya. In her memoir, Flowering Dusk: Things Remembered Accurately and Inaccurately, Young wrote “I have a fondness for The Wonder-Smith; perhaps because I did not invent the stories in the book. I gathered them through twenty-five years of searching, and put a thread of prose round them.” The folktales were collected from story-tellers in Clare, Achill Island, Aranmore, and the Curraun.

Ella Young’s interest in Celtic mythology led to her becoming involved with the growing Irish nationalist movement. Many nationalist writers and artists were looking to Ireland’s history and legends for inspiration, and she befriended fellow Irish writers Æ (George William Russell), Padraic Colum, and William Butler Yeats.  Æ called her “a druidess reincarnated.” Aside from publishing poetry and folklore, Yong was also involved in running guns and ammunition to the Irish Republican Army, and was a member of Cumann na mBAn, a women’s paramilitary organization that took part in the 1916 Easter Rising. She continued to write throughout the war, and in 1925 embarked for America to do a speaking tour about Celtic mythology at universities across the country. She was eventually granted American citizenship and accepted a teaching position at the University of California, Berkeley.  Often described as mystical and otherworldly, Young lived out the rest of her life near the California coast writing and publishing stories and sharing her love of folklore with those around her.

Ukrainian illustrator Boris Artzybasheff fled the Russian Revolution for the United States in 1919. Beginning his career as an engraver, Artzybasheff soon became a book illustrator, some of which he wrote himself, such as Seven Simeons: A Russian Tale, which received a Caldecott Honor award in 1938. He is best known for his magazine covers, and he created over 200 covers for Time magazine alone. Over the course of his career his work evolved to become wonderfully surrealist, he loved anthropomorphizing machines so they would have human attributes and emotions. Even his commercial work in advertising has elements of the absurd. I believe Artzybasheff’s playfulness is evident in the woodcuts he did for The Wonder-Smith, and his illustrations are what drew me to the book.

– Sarah, Special Collections Undergraduate Assistant

On April 9, 1963, Winston Churchill was made an honorary citizen of the United States by John F. Kennedy. A most prestigious honor, it was still just one of many expressions of admiration that the British statesman was offered over the years. A 1946 letter from Churchill to Henry Luce shows him having to turn down honorary degrees from a number of prominent universities. He did, however, agree to a dinner hosted by the Time Inc. publisher at New York’s Union Club. It was a lavish affair, but not everything came off exactly as Luce might have hoped. The large ice sculpture of an eagle with its wings outstretched over mounds of black caviar was melting so quickly that a stream of water ran down the bird’s noble beak. At this Churchill remarked: “The eagle seems to have a cold.”

Winston Churchill. Letter to Henry Luce. February 26, 1946. Time Inc. Records. RG2: Bio files. New-York Historical Society.

Dinner in honor of…Winston S. Churchill…menu and seating arrangement. March 14, 1946. Time Inc. Records. RG2: Bio files. New-York Historical Society.

Processing of the Time Inc. Archive is made possible through the generous support of the Henry Luce Foundation

71 vintage photos captured daily life of Yokohama in the late 1900s.

#🐌 #snail #pet #smallfriend #hyperlapse #timelapse http://ift.tt/1OF6qKr