Fibonacci All Day, Every Day [http://bit.ly/2jiUBF6]

Image Source: Japan Life Science Databases(LSDB), Anatomography. Vomer bone from Anatomography maintained by Life Science Databases(LSDB). Wikimedia Commons.

Vomer: A small, thin bone that separates the left and right nasal cavities in humans. The vomer is located entirely on the sagittal plane.

Could this be the most powerful scientific tool?

Described as “the biggest biotech discovery of the century” by the scientific community, CRISPR-Cas has been all the rage in labs around the world for its exceptional ease and accuracy in editing the gene of almost any organism.

In 2012, UC Berkeley’s world-renowned RNA expert and biochemist Jennifer Doudna was part of a research team that discovered that you could use the CRISPR system as a programmable tool: scientists can precisely target a gene sequence, cutting and changing the DNA at that exact point. 

CRISPR, which stands for “clustered regularly interspaced short palindromic repeats” are repeated DNA sequences that are an essential component of a bacteria’s defense system against viruses.

And what started out as a study to understand the bacterial immune system unwittingly resulted in a powerful technology that has the potential to cure genetic diseases, create more sustainable crops, and even render animal organs fit for human transplants.

We’ve had gene-editing technology for decades, but now, “we’re basically able to have a molecular scalpel for genomes,” says Doudna.

“All the technologies in the past were sort of like sledgehammers.”

GIF source: Business Insider

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What is the evolutionary benefit or purpose of having periods? Why can’t women just get pregnant without the menstrual cycle?

Suzanne Sadedin, Ph.D. in evolutionary biology from Monash University

I’m so glad you asked. Seriously. The answer to this question is one of the most illuminating and disturbing stories in human evolutionary biology, and almost nobody knows about it. And so, O my friends, gather close, and hear the extraordinary tale of:

HOW THE WOMAN GOT HER PERIOD

Contrary to popular belief, most mammals do not menstruate. In fact, it’s a feature exclusive to the higher primates and certain bats*. What’s more, modern women menstruate vastly more than any other animal. And it’s bloody stupid (sorry). A shameful waste of nutrients, disabling, and a dead giveaway to any nearby predators. To understand why we do it, you must first understand that you have been lied to, throughout your life, about the most intimate relationship you will ever experience: the mother-fetus bond.

Isn’t pregnancy beautiful? Look at any book about it. There’s the future mother, one hand resting gently on her belly. Her eyes misty with love and wonder. You sense she will do anything to nurture and protect this baby. And when you flip open the book, you read about more about this glorious symbiosis, the absolute altruism of female physiology designing a perfect environment for the growth of her child.

If you’ve actually been pregnant, you might know that the real story has some wrinkles. Those moments of sheer unadulterated altruism exist, but they’re interspersed with weeks or months of overwhelming nausea, exhaustion, crippling backache, incontinence, blood pressure issues and anxiety that you’ll be among the 15% of women who experience life-threatening complications.

From the perspective of most mammals, this is just crazy. Most mammals sail through pregnancy quite cheerfully, dodging predators and catching prey, even if they’re delivering litters of 12. So what makes us so special? The answer lies in our bizarre placenta. In most mammals, the placenta, which is part of the fetus, just interfaces with the surface of the mother’s blood vessels, allowing nutrients to cross to the little darling. Marsupials don’t even let their fetuses get to the blood: they merely secrete a sort of milk through the uterine wall. Only a few mammalian groups, including primates and mice, have evolved what is known as a “hemochorial” placenta, and ours is possibly the nastiest of all.

Inside the uterus we have a thick layer of endometrial tissue, which contains only tiny blood vessels. The endometrium seals off our main blood supply from the newly implanted embryo. The growing placenta literally burrows through this layer, rips into arterial walls and re-wires them to channel blood straight to the hungry embryo. It delves deep into the surrounding tissues, razes them and pumps the arteries full of hormones so they expand into the space created. It paralyzes these arteries so the mother cannot even constrict them.

What this means is that the growing fetus now has direct, unrestricted access to its mother’s blood supply. It can manufacture hormones and use them to manipulate her. It can, for instance, increase her blood sugar, dilate her arteries, and inflate her blood pressure to provide itself with more nutrients. And it does. Some fetal cells find their way through the placenta and into the mother’s bloodstream. They will grow in her blood and organs, and even in her brain, for the rest of her life, making her a genetic chimera**.

This might seem rather disrespectful. In fact, it’s sibling rivalry at its evolutionary best. You see, mother and fetus have quite distinct evolutionary interests. The mother ‘wants’ to dedicate approximately equal resources to all her surviving children, including possible future children, and none to those who will die. The fetus ‘wants’ to survive, and take as much as it can get. (The quotes are to indicate that this isn’t about what they consciously want, but about what evolution tends to optimize.)

There’s also a third player here – the father, whose interests align still less with the mother’s because her other offspring may not be his. Through a process called genomic imprinting, certain fetal genes inherited from the father can activate in the placenta. These genes ruthlessly promote the welfare of the offspring at the mother’s expense.

How did we come to acquire this ravenous hemochorial placenta which gives our fetuses and their fathers such unusual power? Whilst we can see some trend toward increasingly invasive placentae within primates, the full answer is lost in the mists of time. Uteri do not fossilize well.

The consequences, however, are clear. Normal mammalian pregnancy is a well-ordered affair because the mother is a despot. Her offspring live or die at her will; she controls their nutrient supply, and she can expel or reabsorb them any time. Human pregnancy, on the other hand, is run by committee – and not just any committee, but one whose members often have very different, competing interests and share only partial information. It’s a tug-of-war that not infrequently deteriorates to a tussle and, occasionally, to outright warfare. Many potentially lethal disorders, such as ectopic pregnancy, gestational diabetes, and pre-eclampsia can be traced to mis-steps in this intimate game.

What does all this have to do with menstruation? We’re getting there.

From a female perspective, pregnancy is always a huge investment. Even more so if her species has a hemochorial placenta. Once that placenta is in place, she not only loses full control of her own hormones, she also risks hemorrhage when it comes out. So it makes sense that females want to screen embryos very, very carefully. Going through pregnancy with a weak, inviable or even sub-par fetus isn’t worth it.

That’s where the endometrium comes in. You’ve probably read about how the endometrium is this snuggly, welcoming environment just waiting to enfold the delicate young embryo in its nurturing embrace. In fact, it’s quite the reverse. Researchers, bless their curious little hearts, have tried to implant embryos all over the bodies of mice. The single most difficult place for them to grow was – the endometrium.

Far from offering a nurturing embrace, the endometrium is a lethal testing-ground which only the toughest embryos survive. The longer the female can delay that placenta reaching her bloodstream, the longer she has to decide if she wants to dispose of this embryo without significant cost. The embryo, in contrast, wants to implant its placenta as quickly as possible, both to obtain access to its mother’s rich blood, and to increase her stake in its survival. For this reason, the endometrium got thicker and tougher – and the fetal placenta got correspondingly more aggressive.

But this development posed a further problem: what to do when the embryo died or was stuck half-alive in the uterus? The blood supply to the endometrial surface must be restricted, or the embryo would simply attach the placenta there. But restricting the blood supply makes the tissue weakly responsive to hormonal signals from the mother – and potentially more responsive to signals from nearby embryos, who naturally would like to persuade the endometrium to be more friendly. In addition, this makes it vulnerable to infection, especially when it already contains dead and dying tissues.

The solution, for higher primates, was to slough off the whole superficial endometrium – dying embryos and all – after every ovulation that didn’t result in a healthy pregnancy. It’s not exactly brilliant, but it works, and most importantly, it’s easily achieved by making some alterations to a chemical pathway normally used by the fetus during pregnancy. In other words, it’s just the kind of effect natural selection is renowned for: odd, hackish solutions that work to solve proximate problems. It’s not quite as bad as it seems, because in nature, women would experience periods quite rarely – probably no more than a few tens of times in their lives between lactational amenorrhea and pregnancies***.

We don’t really know how our hyper-aggressive placenta is linked to the other traits that combine to make humanity unique. But these traits did emerge together somehow, and that means in some sense the ancients were perhaps right. When we metaphorically ‘ate the fruit of knowledge’ – when we began our journey toward science and technology that would separate us from innocent animals and also lead to our peculiar sense of sexual morality – perhaps that was the same time the unique suffering of menstruation, pregnancy and childbirth was inflicted on women. All thanks to the evolution of the hemochorial placenta.

https://www.quora.com/what-is-the-evolutionary-benefit-or-purpose-of-having-periods

BIG UPDATE!

I’ve finally finished my biological patches set! After many months of designing, editing, and trial and error, I’m proud to post up photos of the final products!

They are woven with bright, beautiful colors that will endure many washes and adventures to come. They’re only $8 in my store:

https://www.etsy.com/shop/Monsternium

Here are the first five patches in my biological patch set. Once all ten are made, the rainbow of studies will be complete! Each one is illustrated, digitized, and embroidered by me. Stay tuned for more! Next up is herpetology ;)

Galileo’s first telescopes; 17th century, in the Institute and Museum of the History of Science, Florence.

A note on Nuclear Fission

When an atom fissions, it releases a teeny tiny amount of energy ( The decay of one atom of uranium-235 releases about 200MeV or about 3*10-11J.). But atoms are quite small. An atom does not make a big explosion when it splits.

To get a big explosion, you need to split lots and lots and lots and lots and lots and lots and lots and lots and lots of them—many, many trillions of them.

Each one releases only a teeny amount of energy, but when you add up the teeny amount of energy from trillions and trillions and trillions of atoms, then you get a big explosion. (The explosion of 1kg of TNT releases 4MJ).

Coronal section 💕