Entering The House Owned By A Friend Working In The Private Sector, The Grad Student Anxiously Reassesses

Yerres, Path Through the Old Growth Woods in the Park via Gustave Caillebotte

Size: 43x31 cm Medium: oil on canvas

Webb 101: 10 Facts about the James Webb Space Telescope

Did you know…?

1. Our upcoming James Webb Space Telescope will act like a powerful time machine – because it will capture light that’s been traveling across space for as long as 13.5 billion years, when the first stars and galaxies were formed out of the darkness of the early universe.

2. Webb will be able to see infrared light. This is light that is just outside the visible spectrum, and just outside of what we can see with our human eyes.

3. Webb’s unprecedented sensitivity to infrared light will help astronomers to compare the faintest, earliest galaxies to today’s grand spirals and ellipticals, helping us to understand how galaxies assemble over billions of years.

Hubble’s infrared look at the Horsehead Nebula. Credit: NASA/ESA/Hubble Heritage Team

4. Webb will be able to see right through and into massive clouds of dust that are opaque to visible-light observatories like the Hubble Space Telescope. Inside those clouds are where stars and planetary systems are born.

5. In addition to seeing things inside our own solar system, Webb will tell us more about the atmospheres of planets orbiting other stars, and perhaps even find the building blocks of life elsewhere in the universe.

Credit: Northrop Grumman

6. Webb will orbit the Sun a million miles away from Earth, at the place called the second Lagrange point. (L2 is four times further away than the moon!)

7. To preserve Webb’s heat sensitive vision, it has a ‘sunshield’ that’s the size of a tennis court; it gives the telescope the equivalent of SPF protection of 1 million! The sunshield also reduces the temperature between the hot and cold side of the spacecraft by almost 600 degrees Fahrenheit.

8.  Webb’s 18-segment primary mirror is over 6 times bigger in area than Hubble’s and will be ~100x more powerful. (How big is it? 6.5 meters in diameter.)

9.  Webb’s 18 primary mirror segments can each be individually adjusted to work as one massive mirror. They’re covered with a golf ball’s worth of gold, which optimizes them for reflecting infrared light (the coating is so thin that a human hair is 1,000 times thicker!).

10. Webb will be so sensitive, it could detect the heat signature of a bumblebee at the distance of the moon, and can see details the size of a US penny at the distance of about 40 km.

BONUS!  Over 1,200 scientists, engineers and technicians from 14 countries (and more than 27 U.S. states) have taken part in designing and building Webb. The entire project is a joint mission between NASA and the European and Canadian Space Agencies. The telescope part of the observatory was assembled in the world’s largest cleanroom at our Goddard Space Flight Center in Maryland.

Webb is currently being tested at our Johnson Space Flight Center in Houston, TX.

Afterwards, the telescope will travel to Northrop Grumman to be mated with the spacecraft and undergo final testing. Once complete, Webb will be packed up and be transported via boat to its launch site in French Guiana, where a European Space Agency Ariane 5 rocket will take it into space.

Learn more about the James Webb Space Telescope HERE, or follow the mission on Facebook, Twitter and Instagram.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

Mickey Mouse Remastered 

1928 vs. 2014

https://www.youtube.com/watch?v=2VdAV0Yp_Gg

(Image caption: Brain showing hallmarks of Alzheimer’s disease (plaques in blue). Credit: ZEISS Microscopy)

New imaging technique measures toxicity of proteins associated with Alzheimer’s and Parkinson’s diseases

Researchers have developed a new imaging technique that makes it possible to study why proteins associated with Alzheimer’s and Parkinson’s diseases may go from harmless to toxic. The technique uses a technology called multi-dimensional super-resolution imaging that makes it possible to observe changes in the surfaces of individual protein molecules as they clump together. The tool may allow researchers to pinpoint how proteins misfold and eventually become toxic to nerve cells in the brain, which could aid in the development of treatments for these devastating diseases.

The researchers, from the University of Cambridge, have studied how a phenomenon called hydrophobicity (lack of affinity for water) in the proteins amyloid-beta and alpha synuclein – which are associated with Alzheimer’s and Parkinson’s respectively – changes as they stick together. It had been hypothesised that there was a link between the hydrophobicity and toxicity of these proteins, but this is the first time it has been possible to image hydrophobicity at such high resolution. Details are reported in the journal Nature Communications.

“These proteins start out in a relatively harmless form, but when they clump together, something important changes,” said Dr Steven Lee from Cambridge’s Department of Chemistry, the study’s senior author. “But using conventional imaging techniques, it hasn’t been possible to see what’s going on at the molecular level.”

In neurodegenerative diseases such as Alzheimer’s and Parkinson’s, naturally-occurring proteins fold into the wrong shape and clump together into filament-like structures known as amyloid fibrils and smaller, highly toxic clusters known as oligomers which are thought to damage or kill neurons, however the exact mechanism remains unknown.

For the past two decades, researchers have been attempting to develop treatments which stop the proliferation of these clusters in the brain, but before any such treatment can be developed, there first needs to be a precise understanding of how oligomers form and why.

“There’s something special about oligomers, and we want to know what it is,” said Lee. “We’ve developed new tools that will help us answer these questions.”

When using conventional microscopy techniques, physics makes it impossible to zoom in past a certain point. Essentially, there is an innate blurriness to light, so anything below a certain size will appear as a blurry blob when viewed through an optical microscope, simply because light waves spread when they are focused on such a tiny spot. Amyloid fibrils and oligomers are smaller than this limit so it’s very difficult to directly visualise what is going on.

However, new super-resolution techniques, which are 10 to 20 times better than optical microscopes, have allowed researchers to get around these limitations and view biological and chemical processes at the nanoscale.

Lee and his colleagues have taken super-resolution techniques one step further, and are now able to not only determine the location of a molecule, but also the environmental properties of single molecules simultaneously.

Using their technique, known as sPAINT (spectrally-resolved points accumulation for imaging in nanoscale topography), the researchers used a dye molecule to map the hydrophobicity of amyloid fibrils and oligomers implicated in neurodegenerative diseases. The sPAINT technique is easy to implement, only requiring the addition of a single transmission diffraction gradient onto a super-resolution microscope. According to the researchers, the ability to map hydrophobicity at the nanoscale could be used to understand other biological processes in future.

Pleasantville (1998)

“You wanna appease me, compliment my brain!” -Christina Yang

“She has autonomy. She has a strong will. But she can’t move. So in many ways her life is my life. It’s bigger than me, it controls me, and it makes me fight like never before. We spend so much time together that she’s a part of me. She knows how important she is to me. She had childhood cancer. Her heart failed three times. And I was by her side the entire time. I never realized that I could love someone as much as this. She could never hurt me. She could never hurt anyone. We always ask her: ‘Are you angry?’, ‘Are you mad?’ And she always says ‘no.’ She laughs when I laugh. And right now I’m trying not to cry. Because she’ll cry if I cry.” (São Paulo, Brazil)

Moonlight