Natural killer cells are a type of immune cell that protects the body against not only invading pathogens but also cancer, providing an innate defence against these rogue cells. Some tumours, however, keep natural kill cells at bay and thereby avoid destruction. And recent research in lung tumours reveals this natural killer cell exclusion is achieved with the help of another immune cell – the macrophage. The particular culprit is a type of macrophage covered in a protein called TREM2 – an anti-inflammatory factor. Shown above is a lung tumour (green) packed with TREM2-expressing macrophages (red) that are protecting the cancer from attack. Why these macrophages switch allegiance and side with enemy is unclear, but blocking TREM2 while boosting natural killer cell activity was shown to reduce lung tumour growth in mice suggesting a similar approach might be effective in promoting tumour regression in humans too.
Written by Ruth Williams
Image from work by Matthew D. Park and Ivan Reyes-Torres, and colleagues
Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Image copyright held by the original authors
Research published in Nature Immunology, April 2023
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A pure philosopher has no other touchstone for truth than our natural understanding, not theology.
Code that includes commented out code negatively impacts performance. Removing the commented out code improves performance. TFW you realize commented out code is being parsed and it's causing effects.
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My "this isn't complicated" t-shirt has people asking a lot of questions that are already answered by my shirt.
So much clowning on influencers but the real cancer is life coaches talking about law of attraction or whatever yuppie bullshit 'philosophies'. Hang them by their testicles etc
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The economics of the band-aid industry hinges almost entirely on the suffering of small children
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