Researchers at Case Western Reserve University School of Medicine have created the first complete model to describe the role that serotonin plays in brain development and structure. Serotonin, also called 5-hydroxytryptamine [5-HT], is an important neuromodulator of brain development and the structure and function of neuronal (nerve cell) circuits. The results were published in the current issue of The Journal of Neurophysiology online.
“Our goal in the project was to close the gap in knowledge that exists on role of serotonin in the brain cortex, particularly as it concerns brain circuitry, its electrical activity and function,” said Roberto Fernández Galán, PhD, Assistant Professor in the Department of Neurosciences at Case Western Reserve University School of Medicine. “For the first time, we can provide a complete description of an animal model from genes to behavior—including at the level of neuronal network activity, which has been ignored in most studies to date.”
Dr. Galán and his team used high-density multi-electrode arrays in a mouse model of serotonin deficiency to record and analyze neuronal activity. The study supports the importance of the serotonin which is specified and maintained by a specific gene, the Pet-1 gene – for normal functioning of the neurons, synapses and networks in the cortex, as well as proper development of brain circuitry. Serotonin abnormalities have been linked to autism and epilepsy, depression and anxiety. By more fully elucidating the role of serotonin in the brain, this study may contribute to a better understanding of the development or treatment of these conditions.
“By looking at the circuit level of the brain, we now have new insight into how the brain becomes wired and sensitive to changing serotonin levels.” added Dr. Galán.
Version 1 of ‘A Rough Guide to Spotting Bad Science’. Thanks for everyone’s suggestions earlier in the week, attempted to include as many of them as possible!
Download link here: http://wp.me/p4aPLT-ap
In chemistry, flame tests are used to detect the presence of certain elements, primarily metal ions, by analyzing the colour of the flame given off when heated.
above are Lithium (Li), Strontium (Sr), Sodium (Na), Copper(Cu), and Potassium (K).
the drum is filled with hot steam and then sprayed with cold water. the pressure on the outside of the drum is far more than inside. the pressures try to maintain and find balance taking the drum as a casualty.
A new species is evolving before scientists’ eyes in the eastern United States.
Wolves faced with a diminishing number of potential mates are lowering their standards and mating with other, similar species, reported The Economist.
The interbreeding began up to 200 years ago, as European settlers pushed into southern Ontario and cleared the animal’s habitat for farming and killed a large number of the wolves that lived there.
That also allowed coyotes to spread from the prairies, and the white farmers brought dogs into the region.
Over time, wolves began mating with their new, genetically similar neighbors.
The resulting offspring — which has been called the eastern coyote or, to some, the “coywolf” — now number in the millions, according to researchers at North Carolina State University.
Interspecies-bred animals are typically less vigorous than their parents, The Economist reported — if the offspring survive at all.
At about 55 pounds, the hybrid animal is about twice as heavy as a standard coyote, and her large jaws, faster legs and muscular body allow her to take down small deer and even hunt moose in packs, and the animal is skilled at hunting in both open terrain and dense woodland.
An analysis of 437 hybrid animals found that coyote DNA dominates her genetic makeup, with about one-tenth of its DNA from dogs, usually larger dogs such as Doberman pinschers and German shepherds, and a quarter from wolves.
The coywolves have spread into some of the nation’s largest cities — including New York, Boston and Washington — using railway corridors.
The interbreeding allows the animal to diversify her diet and eat discarded food, along with rodents and smaller mammals — including cats, which coywolves eat skull and all — and they have evolved to become nocturnal to avoid humans.
The animals are also smart enough to learn to look both ways before crossing roads.
Not all researchers agree the animal is a distinct species, arguing that one species does not interbreed with another — although the hybrid’s existence raises the question of whether wolves and coyotes are distinct species in the first place.
But scientists who have studied the animal say the mixing of genes has been much faster, extensive and transformational than anyone had noticed until fairly recently.
“(This) amazing contemporary evolution story (is) happening right underneath our nose,” said Roland Kays, a researcher at North Carolina State.
Watch this report on coywolves.
Playing Tetris might help reduce the effects of PTSD. Researchers found that those who played it within 4 hours of seeing traumatic events had fewer flashbacks and intrusive memories. They hope to apply the findings to current treatment, which only deals with the effects after they occur.
Btw, you can play Tetris online for free. Any time. All the time.
Source
Have you ever been listening to a piece of music and experienced intense pleasure, even chills? Valorie Salimpoor and team (2010) conducted research that shows that listening to music can release the neurotransmitter dopamine.
A wide range of music — The researchers used PET (positron emission tomography) scans, fMRI, and psychophysiological measures such as heart rate to measure reactions while people listened to music. The participants provided music that they said gave them intense pleasure and chills. The range of music varied, from classical, folk, jazz, elecronica, rock pop, tango, and more.
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Class in session as Planet X starts it off with our favorite dense objects:
Neutron Stars!
http://www.space.com/22180-neutron-stars.html