Pervasive Pollution: Nurdles (Part 1)

Mapa das novas infecções do ransomware

Assista ao mapa ao vivo das novas infecções do ransomware WannaCry http://www.tecmundo.com.br/ataque-hacker/116649-assista-mapa-ao-vivo-novas-infeccoes-ransomware-wannacry.htm

A Wider Set of Eyes on the Universe

After years of preparatory studies, we are formally starting an astrophysics mission designed to help unlock the secrets of the universe. 

Introducing…

the Wide Field Infrared Survey Telescope, aka WFIRST.

With a view 100 times bigger than that of our Hubble Space Telescope, WFIRST will help unravel the secrets of dark energy and dark matter, and explore the evolution of the cosmos. It will also help us discover new worlds and advance the search for planets suitable for life.

WFIRST is slated to launch in the mid-2020s. The observatory will begin operations after traveling about one million miles from Earth, in a direction directly opposite the sun.

Telescopes usually come in two different “flavors” - you have really big, powerful telescopes, but those telescopes only see a tiny part of the sky. Or, telescopes are smaller and so they lack that power, but they can see big parts of the sky. WFIRST is the best of worlds.

No matter how good a telescope you build, it’s always going to have some residual errors. WFIRST will be the first time that we’re going to fly an instrument that contains special mirrors that will allow us to correct for errors in the telescope. This has never been done in space before!

Employing multiple techniques, astronomers will also use WFIRST to track how dark energy and dark matter have affected the evolution of our universe. Dark energy is a mysterious, negative pressure that has been speeding up the expansion of the universe. Dark matter is invisible material that makes up most of the matter in our universe.

Single WFIRST images will contain over a million galaxies! We can’t categorize and catalogue those galaxies on our own, which is where citizen science comes in. This allows interested people in the general public to solve scientific problems.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com

Molecular body guards for neurons

In the brain, patterns of neural activity are perfectly balanced. The interplay between activating and inhibitory neurotransmitters ensures that the level of activity stays within the physiological range. During an epileptic attack excitation gains the upper hand resulting in the death of neurons. Researchers of the Bonn University Medical School have now discovered a key player in a signal transduction cascade, which protects neurons from hyperexcitation-induced cell death. These results open a new direction for the development of novel therapy options. The results are now published in “The Journal of Neuroscience“.

Pathophysiological activity often triggers neuronal cell death. This can for example be observed after an epileptic insult. The cause for this hyperexcitation is excessive release of the signaling molecule glutamate. “This neurotransmitter can switch on signaling cascades that act neurotoxic”, says Prof. Dr. Schoch McGovern of the Institute of Neuropathology and the Department of Epileptology at the University Clinic Bonn. However, neurons try to protect themselves and prevent the damaging hyperexcitation.

The molecular nature of these “body guards” is so far unresolved. Accumulating evidence shows transcription factors to play an essential role in the processes by which neurons protect themselves. These factors switch on certain genes, which then via signal transduction cascades result in the production of neuroprotective substances. These in turn counteract the damaging glutamate-induced hyperexcitability.

Increased neuronal cell death in the absence of Syt10

The team of Prof. Dr. Schoch McGovern could now show that the protein Synaptotagmin 10 (Syt10) is an integral part of this protective shield. If rats for example experience an epileptic seizure, the amount of Syt10 in the hippocampal formation of the brain strongly increases. The researchers used neurons from mice, in which the Syt10 gene had been ablated, and stimulated them with a glutamate like substance. This treatment resulted in substantial neuronal death.

NPAS4 modulates the production of protective factors

The research team discovered, which transcription factor activates the gene for Syt10 in response to pathophysiological neuronal activity. This essential member of the neuronal body guard is called NPAS4. The researchers cultured rodent neurons and added several transcription factors. NPAS4 activated the Syt10 gene and required Syt10 to exert its neuroprotective function. “NPAS4 triggers a signaling cascade that results in the production of neuroprotective factors”, says Prof. Dr. Schoch McGovern.

Search for novel therapy approaches

The molecular identity of the neuroprotective substances is still unknown. “A potential candidate, the insulin-like growth factor IGF-1, was not able to reverse the increased neuronal cell death in the absence of Syt10”, reports the neurobiologist. The next step therefore is to test other substances. Once the identity of the neuroprotective body guards is revealed, novel avenues for therapy development open up, for example for stroke and epilepsy patients. “The goal would be to administer these protective substances from the outside in order to prevent neuronal cell death in the brain”, says Prof. Dr. Albert Becker, a medical doctor, who was part of the study. However, there is still a long road ahead.

A Couple of Friends It’s Not Your Grandmother’s Needlepoint

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