I Read Once That Shortly Before The Merchant Of Venice Was Written, Queen Elizabeths Doctor (who Was

tag yourself I’m the data noodle

The day my sister, Jessica, discovered Comic Sans, her entire world changed. She’s dyslexic and struggled through school until she was finally diagnosed in her early twenties, enabling her to build up a personal set of tools for navigating the written world. “For me, being able to use Comic Sans is similar to a mobility aid, or a visual aid, or a hearing aid,” she tells me while we’re both visiting our family in Maryland. “I have other ways of writing and reading, but they’re not like they are for someone who’s not dyslexic.” The irregular shapes of the letters in Comic Sans allow her to focus on the individual parts of words. While many fonts use repeated shapes to create different letters, such as a “p” rotated to made a “q,” Comic Sans uses few repeated shapes, creating distinct letters (although it does have a mirrored “b” and “d”). Comic Sans is one of a few typefaces recommended by influential organizations like the British Dyslexia Association and the Dyslexia Association of Ireland. Using Comic Sans has made it possible for Jessica to complete a rigorous program in marine zoology at Bangor University in Wales. […] I asked Jessica to tell me what she’s up against. She’s been told that Comic Sans is “unprofessional. That it’s juvenile. That it’s stupid. That it basically shouldn’t be used for anything at all, unless it is a comic.” There are fonts that have been specifically created for people with dyslexia, all of which lack the clean minimalism or elegant balance and perfect kerning favored by typography snobs. But they are crucial disability aids. Some are free, such as Lexie Readable (which calls itself “Comic Sans for grown-ups”), Open-Dyslexic, and Dyslexie. Others are for purchase or are publisher-owned and unavailable to the general public. But for Jessica, Comic Sans is still the best. “I don’t use Open Dyslexic because it’s not as easy for me to read,” Jessica says. “It’s not my font. I was dyslexic before Open Dyslexic happened. My mind has been getting used to Comic Sans.” Not everyone with dyslexia uses Comic Sans to help them read and write. “Other people with dyslexia find that having colored paper makes it easier,” Jessica says. “Or some people find Arial easier.” Comic Sans and Arial are readily available because they are included by default in many operating systems and word-processing programs, and they are web-safe fonts.

Hating Comic Sans is Ableist by Lauren Hudgins on The Establishment.  (via allthingslinguistic)

Chai Tea

Word for tea in most of the world’s languages are all ultimately related, belonging to two groups of terms.

“Tea” itself belongs to one of those groups.  It was a borrowing from Dutch thee, in turn from tê, the reading of  茶 in the Amoy dialect of Min Nan.  Those languages whose introduction to tea was primaraly from Dutch traders typically use words likewise derived via the Dutch thee.  The Polish herbata is also part of this family, though slightly obscured, being a borrowing from the Latin herba thea.

The other major group is represented by the word chai, a more recent borrowing in English.  Chai was borrowed from the Hindi cāy, which in turn came from a Chinese dialect with a form similar to Mandarin chá.  Languages that use chai-type terms generally were first introduced to tea through overland trade, ultimately to northern China, while those that use tea-type terms were generally introduced to it via sea trade, from Southern China.

Both tê and chá are derived from the same Middle Chinese form, ultimately derived from Proto-Sino-Tibetan *s-la “leaf”.

Sleep suppresses brain rebalancing

Why humans and other animals sleep is one of the remaining deep mysteries of physiology. One prominent theory in neuroscience is that sleep is when the brain replays memories “offline” to better encode them (“memory consolidation”). A prominent and competing theory is that sleep is important for re-balancing activity in brain networks that have been perturbed during learning while awake. Such “rebalancing” of brain activity involves homeostatic plasticity mechanisms that were first discovered at Brandeis University, and have been thoroughly studied by a number of Brandeis labs including the Turrigiano lab. Now, a study from the Turrigiano lab just published in the journal Cell shows that these homeostatic mechanisms are indeed gated by sleep and wake, but in the opposite direction from that theorized previously: homeostatic brain rebalancing occurs exclusively when animals are awake, and is suppressed by sleep. These findings raise the intriguing possibility that different forms of brain plasticity – for example those involved in memory consolidation and those involved in homeostatic rebalancing – must be temporally segregated from each other to prevent interference.

The requirement that neurons carefully maintain an average firing rate, much like the thermostat in a house senses and maintains temperature, has long been suggested by computational work. Without homeostatic (“thermostat-like”) control of firing rates, models of neural networks cannot learn and drift into states of epilepsy-like saturation or complete quiescence. Much of the work in discovering and describing candidate mechanisms continues to be conducted at Brandeis. In 2013, the Turrigiano Lab provided the first ­in vivo evidence for firing rate homeostasis in the mammalian brain: lab members recorded the activity of individual neurons in the visual cortex of freely behaving rat pups for 8h per day across a nine-day period during which vision through one eye was occluded. The activity of neurons initially dropped, but over the next 4 days, firing rates came back to basal levels despite the visual occlusion. In essence, these experiments confirmed what had long been suspected – the activity of neurons in intact brains is indeed homeostatically governed.

Due to the unique opportunity to study a fundamental mechanism of brain plasticity in an unrestrained animal, the lab has been probing the possibility of an intersection between an animal’s behavior and homeostatic plasticity. In order to truly evaluate possible circadian and behavioral influences on neuronal homeostasis, it was necessary to capture the entire 9-day experiment, rather than evaluate snapshots of each day. For this work, the Turrigiano Lab had to find creative computational solutions to recording many terabytes of data necessary to follow the activity of single neurons without interruption for more than 200 hours. Ultimately, these data revealed that the homeostatic regulation of neuronal activity in the cortex is gated by sleep and wake states. In a surprising and unpredicted twist, the homeostatic recovery of activity occurred almost exclusively during periods of activity and was inhibited during sleep. Prior predictions either assumed no role for behavioral state, or that sleeping would account for homeostasis. Finally, the lab established evidence for a causal role for active waking by artificially enhancing natural waking periods during the homeostatic rebound. When animals were kept awake, homeostatic plasticity was further enhanced.

This finding opens doors onto a new field of understanding the behavioral, environmental, and circadian influences on homeostatic plasticity mechanisms in the brain. Some of the key questions that immediately beg to be answered include:

What it is about sleep that precludes the expression of homeostatic plasticity?

How is it possible that mechanisms requiring complex patterns of transcription, translation, trafficking, and modification can be modulated on the short timescales of behavioral state-transitions in rodents?

And finally, how generalizable is this finding? As homeostasis is bidirectional, does a shift in the opposite direction similarly require wake or does the change in sign allow for new rules in expression?

These travel booklets from throughout the UK were collected by Barbara Denison over the course of three decades, part of a larger collection consisting of dozens of volumes. Text-dense and diagram-heavy guides like these were meant to both give guidance while visiting and act as inexpensive momentos afterwards. Most of the booklets in the collection concern cathedrals, abbeys, and ruined castles that Denison visited over the course of her travels.

The History of Hiragana

In Japanese language, we have three types of letters, Kanji, Hiragana, Katakana.

Hiragana’s root is from old Ivrit and Palmyra letters.

The first column:  Phoenician alphabet The second column: Ostracon The third column: Old Aramaic The forth column: Imperial Aramaic The fifth column: Dead Sea scrolls The sixth column: Palmyrene script The seventh column: Palmyra

The first column: Hiragana The second column: Consonants The third column: Vowels The forth column: combined with the consonant and the vowel The fifth column: Sousho-tai (a hand writing style) The sixth column: Kanji

It’s easy:  Form a triangle, then a hexagon, then a bicycle wheel

This is the general mechanism on how a spider spins its web (talk about engineering, right?). When an insect gets caught in its web, the vibrations caused by the insect is felt by the spider which then rushes to engulf its prey.

Now here is the trippy part ; This is the effect of drugs on the pattern of the web.

Hope you are having a great week. Have a good one!

* Spider spinning a web (video) (if you find a better full video let us know)

** Spiders on drugs -  NASA article ; Video

Awesome infographic work by designer Yang Liu. Check out her book ’East Meets West’ (Amazon).

Too much sex causes genitals to change shape, beetle study shows

Sexual conflict between males and females can lead to changes in the shape of their genitals, according to research on burying beetles by scientists at the University of Exeter.

The study, published in the journal Evolution, provides new evidence that conflict over how often mating takes place can lead to males evolving longer penis-like organs and females larger ‘claws’ on their genitalia, within ten generations.

“Our research demonstrates the general importance of conflicts of interest between males and females in helping to generate some of the biodiversity that we see in the natural world. It’s fascinating how genital evolution can happen so fast – in ten generations – showing how rapidly evolutionary changes can occur.”

Paul E. Hopwood, Megan L. Head, Eleanor J. Jordan, Mauricio J. Carter, Emma Davey, Allen J. Moore, Nick J. Royle. Selection on an antagonistic behavioral trait can drive rapid genital coevolution in the burying beetle,Nicrophorus vespilloides. Evolution, 2016; DOI: 10.1111/evo.12938

Fuji-Ya Restaurant, Second to None

In 1968, Reiko Weston opened her new Fuji-Ya restaurant built atop the limestone foundation of a 19th-century flour mill overlooking the Mississippi River and the Stone Arch Bridge. The original Fuji-Ya restaurant operated near 8th St. and LaSalle beginning almost a decade earlier, in 1959, and served fine Japanese food including Charcoal-Broiled Teri-Yaki dinners, seafood dishes, soups, rice plates, and more. Fuji-Ya translates to “second to none” and the new restaurant offered a dining experience like no other in the Twin Cities.

Weston’s restaurant business expanded over the years with Taiga, a Chinese Szechwan restaurant in St. Anthony Main, and The Fuji International in Cedar-Riverside neighborhood, which featured Korean, Chinese, and East Indian food in addition to Japanese food. Her restaurants received numerous awards and Weston herself was named Minnesota Small Business Person of the Year in 1979.

After Reiko Weston passed away in 1988, her daughter Carol stepped in to manage. But in 1990, the City of Minneapolis bought out the historic restaurant in order to make way for the newly designed parkway. About a decade later, Fuji Ya was brought to life again in Uptown in the trendy Lyn-Lake area, where it remains today.

Recently, Fuji-Ya has gained renewed attention as the Park Board makes plans for a $12 million riverfront refresh. Plans include the teardown of the old Fuji-Ya building, expansion of green space, improved pedestrian crossings, and the addition of a new riverfront restaurant. It was announced last week that Sioux Chef owners Sean Sherman and Dana Thompson will open Owamni: An Indigenous Kitchen on the site.

Menu from the original Fuji-Ya restaurant at 814 LaSalle Ave. from the Minneapolis History Collection Menu Collection. Photos from the Star Tribune Photograph Collection at the James K. Hosmer Special Collections, Hennepin County Library.