Samurai Armour.

NCLEX Pharmacology Medical Suffixes

-amil = calcium channel blockers

-caine = local anesthetics

-dine = anti-ulcer agents (H2 histamine blockers)

-done = opioid analgesics

-ide = oral hypoglycemics

-lam = anti-anxiety agents

-oxacin = broad spectrum antibiotics

-micin = antibiotics

-mide = diuretics

-mycin = antibiotics

-nuim = neuromuscular blockers

-olol = beta blockers

-pam = anti-anxiety agents

-pine = calcium channel blockers

-pril = ace inhibitors

-sone = steroids

-statin =antihyperlipidemics

-vir = anti-virais

-zide = diuretics

Jumps, Explained

So, going by the tags on my recent jump gifsets, the difference between jumps is apparently still a source of great bewilderment for some people. Now I could link you to some excellent posts on the topic, but since I am, as usual, an extra lil piece of dirt with too much work to do and a lifetime’s worth of procrastination, I’ve decided to put together my own layman’s guide to identifying figure skating jumps (stressed on the layman part).

First, here be a flowchart, since everybody loves flowcharts, right?

If the flowchart works as intended and you can now tell the jumps apart, great! If you need a bit more explanation and illustration, read on.

Keep reading

The beautiful stone church at Gallarus, Dingle, Co. Kerry, Ireland. It’s circa 1000 years old

The Hippocratic Oath is one of the most famous pieces of medical writing, and it includes some of the basic ethical guidelines for medical practitioners. It is also constantly evolving. The images above come from a version of the oath that we found in the 1634 edition of Peter Lowe’s surgical text. If you compare it to this example of a modern version, you’ll notice some similarities and some differences. Both of them emphasize respecting the work of prior physicians and protecting the patient’s privacy. On the other hand, the modern oath doesn’t begin with an invocation to the gods, and it makes no mention of refusing to assist in abortions or any type of treatment that involves cutting. These changes illustrate how the practice of medicine, and what we expect of medical practitioners, changes over time.

New students at the Washington University School of Medicine are given the chance to devise their own student oath that is similar to the Hippocratic Oath. Take a look at the 2016 class oath here.

On March 3, 1923, Time published it’s first issue. In this prospectus, founders Henry Luce and Briton Hadden describe their vision for a news magazine “aimed to serve the modern necessity of keeping people informed, created on a new principle of COMPLETE ORGANIZATION.”

TIME The Weekly News-Magazine (A Prospectus). Time Inc. Records. New-York Historical Society.

Sleep suppresses brain rebalancing

Why humans and other animals sleep is one of the remaining deep mysteries of physiology. One prominent theory in neuroscience is that sleep is when the brain replays memories “offline” to better encode them (“memory consolidation”). A prominent and competing theory is that sleep is important for re-balancing activity in brain networks that have been perturbed during learning while awake. Such “rebalancing” of brain activity involves homeostatic plasticity mechanisms that were first discovered at Brandeis University, and have been thoroughly studied by a number of Brandeis labs including the Turrigiano lab. Now, a study from the Turrigiano lab just published in the journal Cell shows that these homeostatic mechanisms are indeed gated by sleep and wake, but in the opposite direction from that theorized previously: homeostatic brain rebalancing occurs exclusively when animals are awake, and is suppressed by sleep. These findings raise the intriguing possibility that different forms of brain plasticity – for example those involved in memory consolidation and those involved in homeostatic rebalancing – must be temporally segregated from each other to prevent interference.

The requirement that neurons carefully maintain an average firing rate, much like the thermostat in a house senses and maintains temperature, has long been suggested by computational work. Without homeostatic (“thermostat-like”) control of firing rates, models of neural networks cannot learn and drift into states of epilepsy-like saturation or complete quiescence. Much of the work in discovering and describing candidate mechanisms continues to be conducted at Brandeis. In 2013, the Turrigiano Lab provided the first ­in vivo evidence for firing rate homeostasis in the mammalian brain: lab members recorded the activity of individual neurons in the visual cortex of freely behaving rat pups for 8h per day across a nine-day period during which vision through one eye was occluded. The activity of neurons initially dropped, but over the next 4 days, firing rates came back to basal levels despite the visual occlusion. In essence, these experiments confirmed what had long been suspected – the activity of neurons in intact brains is indeed homeostatically governed.

Due to the unique opportunity to study a fundamental mechanism of brain plasticity in an unrestrained animal, the lab has been probing the possibility of an intersection between an animal’s behavior and homeostatic plasticity. In order to truly evaluate possible circadian and behavioral influences on neuronal homeostasis, it was necessary to capture the entire 9-day experiment, rather than evaluate snapshots of each day. For this work, the Turrigiano Lab had to find creative computational solutions to recording many terabytes of data necessary to follow the activity of single neurons without interruption for more than 200 hours. Ultimately, these data revealed that the homeostatic regulation of neuronal activity in the cortex is gated by sleep and wake states. In a surprising and unpredicted twist, the homeostatic recovery of activity occurred almost exclusively during periods of activity and was inhibited during sleep. Prior predictions either assumed no role for behavioral state, or that sleeping would account for homeostasis. Finally, the lab established evidence for a causal role for active waking by artificially enhancing natural waking periods during the homeostatic rebound. When animals were kept awake, homeostatic plasticity was further enhanced.

This finding opens doors onto a new field of understanding the behavioral, environmental, and circadian influences on homeostatic plasticity mechanisms in the brain. Some of the key questions that immediately beg to be answered include:

What it is about sleep that precludes the expression of homeostatic plasticity?

How is it possible that mechanisms requiring complex patterns of transcription, translation, trafficking, and modification can be modulated on the short timescales of behavioral state-transitions in rodents?

And finally, how generalizable is this finding? As homeostasis is bidirectional, does a shift in the opposite direction similarly require wake or does the change in sign allow for new rules in expression?

I am pretty sure that this cannot be true because I saw an ad from the corn industry that said high fructose corn syrup is good for you…

Fructose alters hundreds of brain genes, which can lead to a wide range of diseases

A range of diseases – from diabetes to cardiovascular disease, and from Alzheimer’s disease to attention deficit hyperactivity disorder – are linked to changes to genes in the brain. A new study by UCLA life scientists has found that hundreds of those genes can be damaged by fructose, a sugar that’s common in the Western diet, in a way that could lead to those diseases.

However, the researchers discovered good news as well: An omega-3 fatty acid known as docosahexaenoic acid, or DHA, seems to reverse the harmful changes produced by fructose.

“DHA changes not just one or two genes; it seems to push the entire gene pattern back to normal, which is remarkable,” said Xia Yang, a senior author of the study and a UCLA assistant professor of integrative biology and physiology. “And we can see why it has such a powerful effect.”

Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine, 2016; DOI: 10.1016/j.ebiom.2016.04.008

Americans get most of their fructose in foods that are sweetened with high-fructose corn syrup, an inexpensive liquid sweetener made from corn starch, and from sweetened drinks, syrups, honey and desserts. The Department of Agriculture estimates that Americans consumed an average of about 27 pounds of high-fructose corn syrup in 2014.  Credit: © AlenKadr / Fotolia

If this Tibetan padlock looks massive that is because it is! And it has not one but THREE equally ginormous keys to open it! It is definitely a very intriguing padlock and indeed something of a puzzle as all three keys must be fitted simultaneously for it to open. There is one lock at the top underneath a panel, another on the side, and a third under a hinged panel on the back. Quite impressive!

We think it dates from the late nineteenth or early twentieth century and was purchased for the museum by Emslie Horniman, who was the son of our founder Frederick Horniman.   

Object no. 13.223

Laplace transform table. Source. (I’m obsessed. <3 And figured y’all would like this one, too!)

Pride and Prejudice by Jane Austen Illustrated by Charles E Brock with an introduction by Austin Dobson London Macmillan and Co Limited 1895 / 1901 452 pages + ads, all page edges gilt, measures 187mm x 130mm

An attractive copy of a classic illustrated edition in the publishers salmon coloured cloth with swirling art nouveau design covers