Me, Thinking About High School:

I’m so happy for you!

Ugh #1

Fucking up when you knew you would is so funny.

Your depression is there to tell you you are a worthless piece of shit who has to fuck other people up.

But you are ready.

Anxiety already prepared you for fucking up. 😝 you knew that would happen

---

I believe in free education, one that’s available to everyone; no matter their race, gender, age, wealth, etc… This masterpost was created for every knowledge hungry individual out there. I hope it will serve you well. Enjoy!

FREE ONLINE COURSES (here are listed websites that provide huge variety of courses)

Alison 

Coursera

FutureLearn

open2study

Khan Academy

edX

P2P U

Academic Earth

iversity

Stanford Online

MIT Open Courseware

Open Yale Courses

BBC Learning

OpenLearn

Carnegie Mellon University OLI

University of Reddit

Saylor

IDEAS, INSPIRATION & NEWS (websites which deliver educational content meant to entertain you and stimulate your brain)

TED

FORA

Big Think 

99u

BBC Future

Seriously Amazing

How Stuff Works

Discovery News

National Geographic

Science News

Popular Science

IFLScience

YouTube Edu

DIY & HOW-TO’S (Don’t know how to do that? Want to learn how to do it yourself? Here are some great websites.)

wikiHow

Wonder How To

instructables

eHow

Howcast

MAKE

Do it yourself

FREE TEXTBOOKS & E-BOOKS

OpenStax CNX

Open Textbooks

Bookboon

Textbook Revolution

E-books Directory

FullBooks

Books Should Be Free

Classic Reader

Read Print

Project Gutenberg

AudioBooks For Free

LibriVox

Poem Hunter

Bartleby

MIT Classics

Many Books

Open Textbooks BCcampus

Open Textbook Library

WikiBooks

SCIENTIFIC ARTICLES & JOURNALS

Directory of Open Access Journals

Scitable

PLOS

Wiley Open Access

Springer Open

Oxford Open

Elsevier Open Access

ArXiv

Open Access Library

LEARN:

1. LANGUAGES

Duolingo

BBC Languages

Learn A Language

101languages

Memrise

Livemocha

Foreign Services Institute

My Languages

Surface Languages

Lingualia

OmniGlot

OpenCulture’s Language links

2. COMPUTER SCIENCE & PROGRAMMING

Codecademy

Programmr

GA Dash

CodeHS

w3schools

Code Avengers

Codelearn

The Code Player

Code School

Code.org

Programming Motherf*?$%#

Bento

Bucky’s room

WiBit

Learn Code the Hard Way

Mozilla Developer Network

Microsoft Virtual Academy

3. YOGA & MEDITATION

Learning Yoga

Learn Meditation

Yome

Free Meditation

Online Meditation

Do Yoga With Me

Yoga Learning Center

4. PHOTOGRAPHY & FILMMAKING

Exposure Guide

The Bastards Book of Photography

Cambridge in Color

Best Photo Lessons

Photography Course

Production Now

nyvs

Learn About Film

Film School Online

5. DRAWING & PAINTING

Enliighten

Ctrl+Paint

ArtGraphica

Google Cultural Institute

Drawspace

DragoArt

WetCanvas

6. INSTRUMENTS & MUSIC THEORY

Music Theory

Teoria

Music Theory Videos

Furmanczyk Academy of Music

Dave Conservatoire

Petrucci Music Library

Justin Guitar

Guitar Lessons

Piano Lessons

Zebra Keys

Play Bass Now

7. OTHER UNCATEGORIZED SKILLS

Investopedia

The Chess Website

Chesscademy

Chess.com

Spreeder

ReadSpeeder

First Aid for Free

First Aid Web

Wolfram Demonstrations Project

Please feel free to add more learning focused websites. 

*There are a lot more learning websites out there, but I picked the ones that are, as far as I’m aware, completely free and in my opinion the best/ more useful.

“If we break up, I want closure. None of this bitter high school mentality that usually follows after someone leaves. I want a long talk about what went wrong, why we couldn’t fix it, and how we’ll move on afterward. I want to know how I made you feel and what thought-process led you to the decision that you’re making. Because if I spent a fraction of my life devoted to loving you, you can’t expect me to let you go without any explanation as to why you’re going in the first place. If I love you, there will always be a piece of me that loves you. So let’s talk it through and forgive each other, neither of us are perfect and we’re both still learning how to love. And that’s okay, it is. But instead of seeing each other the next day and awkwardly pretending we weren’t ever anything at all, let’s forgive each other now and move on. Make peace.”

— Car thoughts #150

Mind blown 😂

Iconic Bellarke lines

To get you through these tough times, until Bellarke is an official ship.

1. Bellamy: If I’m on that list, you’re on that list. Write it down or I will.

2. Bellamy: Clarke, If I don’t see you again-

Clarke: No, You will

3. Bellamy: We can’t lose Clarke! We can’t lose her.

4. Clarke: You’ve got such a big heart Bellamy. People follow you, you inspire them because of this (Touches his heart). But the only way we’re gonna get through this is if you use this too (touches his head).

Bellamy: I got you for that.

5. Clarke: The Heart and the Head.

Bellamy: The Heart and the head

6. Bellamy: I was so mad at you for leaving. I don’t want to feel that way anymore.

7. Bellamy: Besides, I could use a break from keeping you alive.

Clarke: Thank you for keeping me alive.

Bellamy: Well, you don’t make it easy.

8. Diyoza: 283 lives for one. She must be pretty important to you.

Bellamy: She is.

9. Jaha: She’s lucky to have you. You keep her centred.

Bellamy: You got it backwards.

10. Bellamy: Together.

people who can graciously hide that they don’t like people are so terrifying. last year while working on tech for a play i asked my friend how he became friends with another guy on the crew and he got quiet, looked straight into my soul and said “he’s not my friend. i fucking hate him.” i lost 5 years of my life

Antimicrobial Agents  - Cell wall inhibitors

Based on mode of action • divided into families based on chemical structure

 Modes of action Interference with: 

cell wall synthesis 

protein synthesis 

nucleic acid synthesis 

plasma membrane integrity 

metabolic pathway 

Inhibitors of Bacterial Cell Wall (peptidoglycan) Synthesis 

The Beta-lactam Family 

The Glycopeptides 

Peptidoglycan is composed of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) repeat units, and amino acids.  Each NAM is linked to peptide chain and the peptide chains are cross-linked.

β-lactams 

Includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems.

class of broad-spectrum antibiotics containing a β-lactam ring

Bacterial transpeptidase enzymes are responsible for catalysing cross-linking of the peptide chains

β-lactam ring bind to these transpeptidases – this inhibits cross-linking between peptide chains and prevents synthesis of stable PG

Cell wall synthesis ceases and the bacterial cells eventually die due to osmotic instability or autolysis. 

Glycopeptides 

Polypeptide agents - basic structural elements amino acids 

Vancomycin: 

complexes with peptide portion of peptidoglycan’s precursor units 

vancomycin is a large hydrophilic molecule able to form hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

preventing PG transglycosylation reaction – PG precursor subunits (NAG-NAM+peptide) cannot be inserted into peptidoglycan matrix;

Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis

Uses:  serious Gram positive infections e.g. MRSA wound infection

Adverse effects:

damage to auditory nerve 

hearing loss (ototoxicity) 

“Red man/neck” syndrome - rash on face, neck, upper torso 

Pregnancy - physiology

Hormones

hCG - human chorionic gonadotropin - present in blood and urine, produced by blastocyst and placenta

Low levels of hCG could mean miscarriage, ectopic pregnancy, miscalculation of dates

High levels = molar pregnancy (cells that normally form a baby dysfunction and form cysts instead), multiple pregnancy (twins etc), miscalculation of dates

Progesterone increases fat deposition in early weeks and stimulates appetite

Increased oestrogen from corpus luteum promotes mammary gland development (breasts enlarge)

And inhibits ovulation via negative feedback [OES decreases GnRH release by hypothalamus –> linhibition of FHS and LH –> no ovulation]

Relaxin (secreted by corpus luteum) softens connective tissue in preparation for labour - not specific, all joints can be affected

Peaks in early and late pregnancy

Physical changes

Blood pressure

As early as 4 weeks into pregnancy 

plasma volume increase

caused by the affects of oestrogen and progesterone on the kidneys

OES and Prg cause vasodilation 

less resistance = less pressure

Heart rate increases by 25% to compensate

stroke volume increases 

increased overall cardiac output by 50% in third trimester

Direct action of enlarged uterus:

compresses the descending aorta and inferior vena cava 

decreased venous return - less blood in means less blood out, less blood in ventricle –> reduced pressure on walls –> reduced force to exit –> reduced placental perfusion

increased aortic pressure

increased heart rate

[shouldn’t sleep on back for this reason]

Outcomes:

Fall in blood pressure (can cause collapse if serious)

Can cause foetal hypoxia even without mother symptoms

Haematological changes

red cell mass increase by 20% (renal - increased erythropoietin production in response to detection of blood oxygenation and sodium/water balance)

Plasma volume increases more than RBC count does, causing the impression of decreased haemoglobin (anaemia)

Increased tendency to clot (hypercoagulable)

due to increase in clotting factors and plasma fibrinogen

platelet production increase (however count drops due to increase in activity and consumption) - function remains normal]

WBC count may increase due to an increase in granulocytes

Respiratory changes

Increased chest diameter, diaphragmatic expression and elevation

dyspnoea common (difficulty breathing)

breathing becomes more costal (mouth) than abdominal 

mainly mediated by progesterone levels (cause bronchial and smooth muscle relaxation and hypersensitivity to CO2)

Changes to the urinary system

cardiac output increase –> increase in renal plasma flow and glomerular filtration

increase in urea, creatinine, urate and biocarbonate clearance 

with progesterone, renin and aldosterone up water retention increases

can lead to urinary stasis and increased risk of UTI

Any drugs given that are excreted renally must be given in much higher quantities consequently

Gastrointestinal changes

Appetite increase + cravings 

Gastric reflux sphincter relaxation (increased indigestion, also due to increased intra-gastric pressure (expanding uterus)) 

gallbladder dilated 

GI motility decreased and transit time slower 

albumin and protein decrease 

cholesterol twice normal value

Muskuloskeletal 

Calcium reuptake into bloodstream results in mild decalcification of bones 

relaxin softens joints (pubic symphysis + alters gait (waddling))

abdominal muscles stretch to elastic limit 

stretch marks (stria gravidarum) caused by rupture of elastic fibres and small blood vessels 

Reproductive changes

Massive increase in mass

Placenta growth (nutrition, excretion, immunity, endocrine) 

Parental blood supply 

If you're tired, read this. Please.

Hey, amigo.

It’s hard, isn’t it?

I know. Sometimes, it’s painful too.

Sometimes you really wanna give up, throw the books, hide in a corner and never take any action again.

I understand. I really do.

But I’m not here to collaborate on the pity party. I’m not going to join in on the groaning challenge, or complain about how hard it is.

First, get this though. It is hard. I won’t lie. It is worth groaning upon. Maybe one or two pity parties are affordable too.

Yet, there’s a pact we’ve make together, and I’d like to remind you of it, before we talk further. New here? We call it the Shush Pact.

Don’t do it. Don’t complain. Don’t whine. Don’t give in so easily. Don’t.

Go ahead. Make the pact. Now.

Go on! Do it.

Tell yourself, today’s hard. Tiring. But, I won’t give in to this. Nor will I complain and moan about it, and waste my energy. Not today, Amelia! Today’s not that day.

Done?

Sure?

Okay. Let’s go.

If you’re tired.

If you’re tired, exhausted of the hustle, and almost at your breaking point, I want you to remember how MUCH this means to you.

I don’t know what’s driving you nuts. Maybe it’s a math problem you just can’t crack. The presentation due next week that isn’t up to the mark. Maybe it’s 3 gigantic books you have to read up on before your next theology class. Perhaps your business has come at a standstill, and you can’t get it to grow. Or maybe you hate your job, and have finally, bravely, taken the step to work the 6 hours after you come home on building the art portfolio of your dreams, because in your heart, you’ve always been an artist. Maybe you’re juggling three jobs and working late nights to save enough money to catch the dream bus.

I don’t know. But I do know that it means a lot to you.

I know how passionate you’re about this, and how much it means to you.

And yet, you’re tired.

You’re tired of it!

You’re tired of studying so much. You’re tired of DMing every business in town, to have none reply back. You’re tired of working so much, handling so much, and you feel like you haven’t had a break since you were a kid. You’re tired of the pressure, you’re tired of the hustle and you just… wanna quit.

Don’t.

Please.

It’s hard to be positive in this dark, numb time and you’re starting to work mechanically, questioning your existence with every hour, but I have to make you understand! You’re worth this! You’re so worthy of this, my love.

Please don’t quit.

Don’t give up. It’s hard, but seal those lips, and trust your gut. I know you can make it. You’ve worked so hard for this! You’ve struggled so much, invested in so many weeks of work, and right now, at your breaking point, I want you to realise that you’re worthy. Of getting that grade, that degree, finding a job you love, your crazy ambitions of opening a flower shop… everything! All of it!

You deserve the world.

Listen to me. Open your ear and listen: you’re tired, yes. But here’s the truth. You’re not done yet.

You’ve got so much to prove to yourself. So many identities to identify yourself with. Exams to slay, jobs to get, money to make, dreams to build, people to meet and love to spread.

Listen. There’s more to this. There’s more to YOU.

Don’t give up now.

Not today.

You’re not done yet.

Tiredness will pass, and I want you to just try pushing through this. Just try. You’ll see you’re so capable of winning and it’ll blow your mind when you look back and realise the strength you truly possessed because you were able to push through.

Winning is your blood. It’s your oxygen.

Tiredness is a toxic. A poison. You’re not tired, you just think you are. When the human brain says it’s done, it’s actually got 70% more to give.

Don’t forget. Your legacy awaits. If this truly means everything to you, if you’ve already put in hundreds of hours of work into this, PUSH THROUGH! You’ve got to, because your future self deserves a better life! Don’t let them tell you that you need a break. A Hawaii vacation. They’ll say you’re getting nowhere and urge you to take a break.

You and me, we both know you don’t need one. You just needed a reminder of your capabilities.

And I’ve given you that now.

Just remember, you’re not done yet.

So fuck tiredness.

Go win.