Hey Loves! I Wanted To Make Some Food And Really Liked How These Turned Out. I Hope You Enjoy And As

Hi guys! As a Christmas present I decided to convert all 30 items of Everyday Clutter Kit to base game.

🎄 Merry Christmas 🎄

Hey!

I’ve noticed recently that the Domaine du Clos kitchen didn’t uploaded on CurseForge, now it’s available! 🎉

Download Domaine du Clos (CurseForge)

Love Bonito (8 items)

❤ Base game compatible

❤ Teen - elder

❤ Female only.

Download ( EarlyAccess 9March)

Custom Content i used in pic :

KylieHairstyle  BonnieHairstyle  ArletteHairstyle  SusanHairstyle 

Celestial Shoes  Lissa Shoes 

Instagram

Thank you for loving my cc & and this is the T.O.U . ❤

Things you can't do :

-Re-upload , Re-edit , Put behind paywalls , Steal or Claim it as yours .

PSA:

Acetaminophen/paracetamol has a hard stop upper dose limit, above which it becomes extremely toxic.

That limit is 4g (8 “extra strength” (500mg) tablets) in 24 hours (about 2 tablets every 6 hours).

A single dose of 22 extra strength tablets can kill you.

Taking 12 or more tablets per day for more than a week can also kill you (this is about 3 tablets every 6 hours).

Symptoms of overdose take up to 24 hours to manifest, and are fairly difficult to distinguish from other problems. They include abdominal pain (especially right upper quadrant), nausea, malaise, and confusion.

The antidote (n-acetylcystine) must be given within 8hours of ingestion in order to be useful.

After 10 hours the only thing that will work is a liver transplant.

You might think “why would I ever accidentally take so much?”

Well, acetaminophen is in almost everything in the cold/flu/pain aisle. Migraine combos like Excedrin, cold and flu combos like NyQuil, basically anything that says “non-aspirin pain relief”, and anything that’s branded as a fever reducer. It’s all probably acetaminophen/paracetamol.

So the goal of this post is to get you to read the labels on your medications. Because taking taking Tylenol and NyQuil together for a week (like you might if you had the flu) could kill you.

and therein lies the real horror of bullying, of abuse, of oppression: you stop being yourself. you begin to chip away at everything that makes you you in order to create what's least likely to get you hit. you begin to view life as a series of mitigating choices - how much can you take away before you just become a corpse?

New posepack: Spellcasters

A while ago I started making these poses for a character of mine, although he didn’t need them in the end (which is why there will, at some point, be a version of these with a walking stick instead). BUT it got me thinking that there aren’t many (any?) magic poses for spellcasters who use wheelchairs, so I finally got round to finishing it up.

The first four poses have four different emotions (neutral, angry, sad, happy - just basic stuff) and then the rest are just some random ones that I felt like doing.

You will need: - Windkeepers Modern Wheelchair by @teabaker  - Book by @inabadromance for pose 7

TOU: please don’t steal, redistribute, put behind a paywall, or alter (beyond basic tweaking) in renders thank yooouuu. These are free my dudes, play nicely.

Download here (CurseForge) or alternative download here (SFS) Like my poses? You can now buy me a coffee! 

I’d love to see what you do with them so feel free to tag me here, on Twitter, or Instagram.

@ts4-poses

Pharmacology Unveiled: How Medications Work on a Molecular Level"

Explore the science of pharmacology and delve into the mechanisms of action of commonly prescribed medications, shedding light on how they interact with the body's systems.

In the multifaceted domain of pharmacology, an intricate symphony of molecular interactions orchestrates the therapeutic effects of medications. A profound comprehension of the molecular underpinnings of pharmacological actions is indispensable for healthcare professionals, pharmaceutical scientists, and researchers. In this discourse, we embark on a comprehensive exploration of pharmacodynamics, elucidating the profound intricacies of how medications function at the molecular level.

Pharmacodynamics: A Multilayered Discipline

Pharmacodynamics constitutes the extensive scrutiny of the manner in which drugs interlace with specific molecular targets, often referred to as receptors or enzymes, within the human organism. Medications are meticulously designed to effectuate alterations in biochemical pathways, receptor kinetics, or enzymatic processes, aiming to modulate physiological phenomena to alleviate symptoms or remediate pathological states.

Receptor-Mediated Pharmacological Actions

A pivotal facet of pharmacodynamics lies in the receptor-mediated actions of medications. Receptors are intricate protein entities, frequently situated on the extracellular or intracellular domains of cells, that play a pivotal role in cellular communication and homeostasis. When a medication interfaces with a receptor, it initiates a cascade of molecular events, which, contingent upon the context, may potentiate or impede the cellular response.

Agonists and Antagonists: Puppets of Molecular Dance

In the intricate theater of pharmacodynamics, medications assume roles as either agonists or antagonists. Agonists aptly mimic the endogenous ligands or signaling molecules, seamlessly integrating into the receptor's binding pocket. This engagement sets forth a conformational alteration in the receptor, instigating cellular events replicating or augmenting the physiological response. Conversely, antagonists function as molecular antagonists, obstructing the receptor and forestalling the binding of endogenous signaling molecules. Consequently, the physiological response is negated or attenuated.

Enzymatic Interference: Orchestrating Biochemical Concertos

Certain medications orchestrate their therapeutic influence through the intricate domain of enzyme inhibition. Enzymes are the catalytic workhorses governing biochemical transformations in biological systems. Medications that selectively inhibit or modulate these enzymes effectively regulate the pace or character of these metabolic reactions, rendering them invaluable in conditions characterized by aberrant enzyme function.

Ion Channel Choreography: Modulating Electrophysiological Ballets

A notable mechanism of pharmacological action entails the modulation of ion channels. These proteinaceous conduits, reposing within cellular membranes, govern the flux of ions across these barriers. Medications designed to engage with ion channels effectively influence the electrochemical signaling within cells. The modulation of ion channels is instrumental in conditions such as arrhythmias, epilepsy, and neuropathic pain.

Pharmacogenetics: Personalizing Medication Regimens

The burgeoning realm of pharmacogenetics delves into the impact of an individual's genetic repertoire on their medication response. Genetic polymorphisms can significantly influence drug metabolism, receptor sensitivities, and pharmacological efficacy. Tailoring medication regimens to align with an individual's genetic makeup represents a burgeoning paradigm in personalized medicine.

Pharmacology unfolds as an intricate tapestry of molecular engagements and multifarious mechanisms. Medications, hewn with precision, are intended to engage with specific molecular entities, be it receptors, enzymes, or ion channels, aiming to modulate intricate biochemical processes to achieve therapeutic ends.

References

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2015). Rang & Dale's Pharmacology. Elsevier.

Katzung, B. G., & Trevor, A. J. (2021). Basic & Clinical Pharmacology. McGraw-Hill Education

Brunton, L. L., Knollmann, B. C., & Hilal-Dandan, R. (2020). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. McGraw-Hill Education.

Desert at Dusk (1928) by Audley Dean Nicols