Real Quick Lil Warm Up Thing  (人◕ω◕)

Jan 8 2018/ 1/100 days

Today was my first day back at school! I have lots of work to do already on my giant research project.It is also my first time using my bullet journal for school and I quite like it (although this weeks spread is messed up)

school mindset

essays - make each essay you write better than the last


 small assignments - aim for 100s, expect 100s, get 100s


 homework - pretend they’re assignments


 homework that’s not graded - pretend! they’re! assignments!


 tests - study for 100s, expect less


 long term projects - act like it’s due in four days -even when it’s not- until you’re done with it


 group projects - do not get angry


 presentations - pretend you’re obama

disclaimer - this works for me, it may not work for everybody, do not push yourself too hard!!

Study identifies new target to preserve nerve function

Scientists in the Vollum Institute at OHSU have identified an enzyme that plays a crucial role in the degeneration of axons, the threadlike portions of a nerve cell that transmit signals within the nervous system. Axon loss occurs in all neurodegenerative diseases, so this discovery could open new pathways to treating or preventing a wide array of brain diseases.

The research team discovered a new role of the enzyme Axundead - or Axed - in promoting the self-destruction of axons. They found that when Axed function was blocked, injured axons not only maintained their integrity but remained capable of transmitting signals within the brain’s complex circuitry for weeks. Their research was published July 5 in the journal Neuron.

“If you target this pathway, you have a really good chance of preserving the functional aspects of neurons after a variety of types of trauma or injury,” said senior author Marc Freeman, Ph.D., director of the Vollum Institute at OHSU. “It’s a very attractive therapeutic target.”

Freeman conducted the work in the Department of Neurobiology at the University of Massachusetts Medical School. He has since been recruited to head the Vollum Institute, which conducts cutting-edge basic research into how the nervous system works at a molecular level.

Severing axons, or axotomy, is a simple way to study the molecular basis of neurodegeneration as it leads to the activation of explosive axonal degeneration. In the laboratory, researchers using this technique can identify pro-degenerative genes with great specificity, especially when using sophisticated genetic approaches in the fruit fly Drosophila, Freeman’s primary research model organism. Drosophila shares these same pathways with humans. Previous work by Freeman’s lab identified another enzyme, a gene called SARM, which was the first shown to activate a process that causes axons to disintegrate when damaged.

In the current study, Freeman and colleagues identified Axed, showed that it functions downstream of SARM to execute axonal degeneration, and, surprisingly, that the protection afforded by blocking Axed was even stronger than SARM.

“There was really nothing we could do to kill axons where Axed function was blocked,” Freeman said.

From an evolutionary perspective, Freeman said SARM and Axed function are likely important in the peripheral nervous system after injury because programmed axon death allows for efficient packaging of damaged cellular materials for removal by immune cells. This process thereby clears the pathway for new neuronal processes to regrow, reinnervate tissues, and recover function.

From a therapeutic perspective, the goal of the work is to understand at the molecular level how axons degenerate, and block those pathways in patients to preserve nervous system function. In many nervous system injuries axons are not severed but become stretched or crushed, which activates the SARM-dependent death program and drives axon loss. In those cases, it’s imperative to block SARM and Axed signaling to preserve axon integrity, and in turn neuronal function. At the same time, Freeman and others have shown that SARM-dependent signaling pathways also drive axon loss in neurodegenerative conditions including glaucoma, traumatic brain injury and peripheral neuropathy. This suggests the notion of an ancient and conserved axon death signaling pathway that is widely activated to drive axon loss. Since axon loss is a universal feature of neurodegenerative diseases, it seems likely that blocking this pathway could have enormous therapeutic benefit.

“If we can find ways to block it, maybe we can preserve function in a wide array of patients who have lost axons through neurodegenerative diseases or other neural trauma,” Freeman said.

Best advice I’ve received so far

the time you take being jealous of other people’s success is the time you could be using to build your own

you’re never going to “feel like it”

doing and practicing now is better than waiting for the perfect moment

eliminate people with toxic habits from your life

you are in control. Everything you’ve done up to this moment led you here. Therefore, your future is determined by what you do now.

everything is as it should be and only later in life you can connect the dots.

self discipline will give you freedom. consistency will give you results

everything is temporary. You should find freedom in this concept

the rich stay rich acting poor and the poor stay poor acting rich

being healthy means finding a balance between the good and the bad

the people that outranked you have outworked you.

you can’t be grateful and negative at the same time.

Meditate on these statements. They are so very powerful! Xxx

Finally got around to making my January spread It's not much but I like how it turned out

My beautiful alter set up

hello!

I’m Anna - I’ve recently restarted running my studyblr in the hopes of it helping me motivate myself and help me take an initiative in being more organized for the new year. Hopefully I’ll meet some new people in the community and we can be friends!

about me:                                                                                                                        - I love tomatoes                                                                                                     - I love running (short distance)                                                                                                  - I just recently started highschool                                                                                                  - Yellow is my fav color                                                                                                  - I speak Russian and English                                                                                                  - I can play the ukulele                                                                                                - I live for memes 

*  if we have anything in common, message me! we can bond ha *

my fav studyblrs 

@cloudedstudy - @studyblr - @studign - @emmastudies  - @acadmia - @physike - @wildliners - @intellectys - @studynine - @stu-pidest - @teacomets - @sadgirlstudying - @no-cake-where - @hannahstudies - @studythetics - @revisoin - @aou - @studyisms - @altairstudy - @minimalismstudies

pls reblog or like if you’re a studyblr, I’m always looking for new studyblr accounts to follow. 

hope you all had a great 2017 and have an even better 2018!

Can’t stop, won’t stop.

"Faggot"

while you’re scrolling through your dash I just wanted to quickly say that you are a good and intelligent, kind and capable person and deserve the universe

thanks for your attention